133343-26-7

Basic information

• Product Name: (4R,5R)-4,5-Bis-(3-benzyloxy-4-methoxy-phenyl)-[1,3,2]dioxathiolane 2,2-dioxide
• Synonyms: (4R,5R)-4,5-Bis-(3-benzyloxy-4-methoxy-phenyl)-[1,3,2]dioxathiolane 2,2-dioxide
• CAS NO: 133343-26-7
• Molecular Weight: 548.614
• Mol File: 133343-26-7.mol

Chemical Properties

• CAS DataBase Reference: (4R,5R)-4,5-Bis-(3-benzyloxy-4-methoxy-phenyl)-[1,3,2]dioxathiolane 2,2-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5R)-4,5-Bis-(3-benzyloxy-4-methoxy-phenyl)-[1,3,2]dioxathiolane 2,2-dioxide(133343-26-7)
• EPA Substance Registry System: (4R,5R)-4,5-Bis-(3-benzyloxy-4-methoxy-phenyl)-[1,3,2]dioxathiolane 2,2-dioxide(133343-26-7)

Safety Data

• Hazardous Substances Data: 133343-26-7(Hazardous Substances Data)

Upstream product

• 6346-05-0 3-benzyloxy-4-methoxybenzaldehyde 
• 140687-76-9 (1R,2R)-1,2-Bis-(3-benzyloxy-4-methoxy-phenyl)-ethane-1,2-diol 
• 133343-20-1 3,3'-Dibenzyloxy-4,4'-dimethoxystilben 
• 133343-22-3 (4R,5R)-4,5-Bis-(3-benzyloxy-4-methoxy-phenyl)-[1,3,2]dioxathiolane 2-oxide 

Downstream Products

• 135574-24-2 Benzoic acid (R)-((S)-2-benzoyl-7-benzyloxy-6-methoxy-1,2-dihydro-isoquinolin-1-yl)-(3-benzyloxy-4-methoxy-phenyl)-methyl ester 
• 135574-25-3 (4S,5R)-4,5-Bis-(3-benzyloxy-4-methoxy-phenyl)-3-(2,2-dimethoxy-ethyl)-oxazolidin-2-one 
• 135574-27-5 (1R,10bS)-9-Benzyloxy-1-(3-benzyloxy-4-methoxy-phenyl)-6-hydroxy-8-methoxy-1,5,6,10b-tetrahydro-oxazolo[4,3-a]isoquinolin-3-one 
• 135574-69-5 Benzoic acid (R)-((S)-2-benzoyl-7-hydroxy-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-1-yl)-(3-hydroxy-4-methoxy-phenyl)-methyl ester 
• 135574-28-6 [(4S,5R)-4,5-Bis-(3-benzyloxy-4-methoxy-phenyl)-2-oxo-oxazolidin-3-yl]-acetaldehyde 
• 135574-26-4 (1R,10bS)-9-Benzyloxy-1-(3-benzyloxy-4-methoxy-phenyl)-8-methoxy-1,10b-dihydro-oxazolo[4,3-a]isoquinolin-3-one 
• 83177-82-6 α-hydroxy-norreticuline 
• 70592-30-2 7-benzyloxy-6-methoxyisoquinoline 
• 13168-51-9 N-benzoyl-norreticuline 
• 135574-23-1 (1R,2S)-1,2-Bis-(3-benzyloxy-4-methoxy-phenyl)-2-(2,2-dimethoxy-ethylamino)-ethanol 
• 133343-36-9 Acetic acid (R)-((S)-4-acetoxy-7-benzyloxy-6-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-yl)-(3-benzyloxy-4-methoxy-phenyl)-methyl ester 
• 133343-27-8 Acetic acid (1R,2S)-1,2-bis-(3-benzyloxy-4-methoxy-phenyl)-2-[(2,2-dimethoxy-ethyl)-methyl-amino]-ethyl ester 
• 133343-35-8 Acetic acid (R)-((S)-7-benzyloxy-4-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-yl)-(3-benzyloxy-4-methoxy-phenyl)-methyl ester 
• 133343-25-6 (S)-7-Benzyloxy-1-[(R)-(3-benzyloxy-4-methoxy-phenyl)-hydroxy-methyl]-6-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-ol 

Relevant articles and documents

ASYMMETRIC SYNTHESIS OF (R)-RETICULINE - A NEW STRATEGY FOR THE ASYMMETRIC SYNTHESIS OF ISOQUINOLINES VIA ENANTIOSELECTIVE EPOXIDATION OR DIHYDROXYLATION

A new strategy for the asymmetric synthesis of 1-benzyl-1,2,3,4-tetrahydroisoquinolines 7 - 9 has been developed.The route involves introduction of asymmetry via enantioselective epoxidation or dihydroxylation of corresponding stilbene precursors followed by aminolysis and Pomeranz-Fritsch cyclization.The strategy has been successfully applied to the asymmetric synthesis of (R)-reticuline (9), the key intermediate in the synthesis of morphine alkaloids on the biomimetic route.