135576-51-1

Basic information

• Product Name: 4-Piperidinone, 1-[(2-chlorophenyl)methyl]-
• CAS NO: 135576-51-1
• Molecular Formula: C12H14ClNO
• Molecular Weight: 223.702
• Mol File: 135576-51-1.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 4-Piperidinone, 1-[(2-chlorophenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Piperidinone, 1-[(2-chlorophenyl)methyl]-(135576-51-1)
• EPA Substance Registry System: 4-Piperidinone, 1-[(2-chlorophenyl)methyl]-(135576-51-1)

Safety Data

• Hazardous Substances Data: 135576-51-1(Hazardous Substances Data)

Upstream product

• 41661-47-6 piperidin-4-one 
• 611-19-8 1-chloro-2-(chloromethyl)benzene 
• 41979-39-9 4-piperidone hydrochloride 
• 611-17-6 1-bromomethyl-2-chlorobenzene 

Downstream Products

• 634616-97-0 1-[1-[1-(2-chlorobenzyl)piperidin-4-yl]piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one 
• 1074762-25-6 C₂₄H₂₈Cl₂N₄O 
• 1373271-08-9 1-{1-[(2-chlorophenyl)methyl]piperidin-4-yl}-4-(1,3-thiazol-2-yl)-1,4-diazepane 
• 1373271-06-7 2-(4-{1-[(2-chlorophenyl)methyl]piperidin-4-yl}-1,4-diazepan-1-yl)-N-(cyclopropylmethyl)-1,3-thiazole-4-carboxamide 
• 1373273-25-6 1-{1-[(2-chlorophenyl)methyl]piperidin-4-yl}-1,4-diazepane 
• 55142-85-3 ticlopidine 

Relevant articles and documents

1-BENZYLSPIRO[PIPERIDINE-4,1′-PYRIDO[3,4-b]indole] ‘co-potentiators’ for minimal function CFTR mutants

We previously identified a spiro [piperidine-4,1-pyrido [3,4-b]indole] class of co-potentiators that function in synergy with existing CFTR potentiators such as VX-770 or GLGP1837 to restore channel activity of a defined subset of minimal function cystic fibrosis transmembrane conductance regulator (CFTR) mutants. Here, structure-activity studies were conducted to improve their potency over the previously identified compound, 20 (originally termed CP-A01). Targeted synthesis of 37 spiro [piperidine-4,1-pyrido [3,4-b]indoles] was generally accomplished using versatile two or three step reaction protocols with each step having high efficiency. Structure-activity relationship studies established that analog 2i, with 6′-methoxyindole and 2,4,5-trifluorobenzyl substituents, had the greatest potency for activation of N1303K-CFTR, with EC50 ～600 nM representing an ～17-fold improvement over the original compound identified in a small molecule screen.

CXCR4 Receptor Antagonists

Disclosed are compounds that are antagonists of the CXCR4 receptor.

Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties

This Letter describes the first account of the synthesis and SAR, developed through an iterative analogue library approach, of analogues of the highly selective M1 allosteric agonist TBPB. With slight structural changes, mAChR selectivity was maintained, but the degree of partial M1 agonism varied considerably.