135579-18-9Relevant academic research and scientific papers
Nickel-Catalyzed 1,2-Diarylation of Simple Alkenyl Amides
Derosa, Joseph,Kleinmans, Roman,Tran, Van T.,Karunananda, Malkanthi K.,Wisniewski, Steven R.,Eastgate, Martin D.,Engle, Keary M.
supporting information, p. 17878 - 17883 (2019/01/04)
A nickel-catalyzed conjunctive cross-coupling of simple alkenyl amides with aryl iodides and aryl boronic esters is reported. The reaction is enabled by an electron-deficient olefin (EDO) ligand, dimethyl fumarate, and delivers the desired 1,2-diarylated products with excellent regiocontrol. Under optimized conditions, a wide range of amides derived from 3-butenoic acid, 4-pentenoic acid, and allyl amine are compatible substrates. This method represents the first example of regiocontrolled 1,2-diarylation directed by a native amide functional group. Computational analysis sheds light on the potential substrate binding mode and the role of the EDO ligand in the reductive elimination step.
Aryl radical cyclisations: Quinoline, isoquinolone, and 1-benzazepin-2-one rings via 6- and 7-exo cyclisations
Clark,Jones,McCarthy,Storey
, p. 2829 - 2832 (2007/10/02)
The cyclisation of aryl radicals derived by treatment of aryl halides (1a), (1b), (4), (7a), (7b), and (10) with tri-n-butyltin hydride has been investigated.
