1355990-15-6

Basic information

• Product Name: (S)-1-[2-allyl-3-(4-methoxybenzyloxy)phenyl]-6-benzyloxyundec-2-yn-1-one
• Synonyms: (S)-1-[2-allyl-3-(4-methoxybenzyloxy)phenyl]-6-benzyloxyundec-2-yn-1-one
• CAS NO: 1355990-15-6
• Molecular Weight: 524.7
• Mol File: 1355990-15-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-1-[2-allyl-3-(4-methoxybenzyloxy)phenyl]-6-benzyloxyundec-2-yn-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-[2-allyl-3-(4-methoxybenzyloxy)phenyl]-6-benzyloxyundec-2-yn-1-one(1355990-15-6)
• EPA Substance Registry System: (S)-1-[2-allyl-3-(4-methoxybenzyloxy)phenyl]-6-benzyloxyundec-2-yn-1-one(1355990-15-6)

Safety Data

• Hazardous Substances Data: 1355990-15-6(Hazardous Substances Data)

Upstream product

• 1355990-09-8 2-allyl-3-(4-methoxybenzyloxy)benzaldehyde 
• 1355990-13-4 (S)-1-[2-allyl-3-(4-methoxybenzyloxy)phenyl]-6-benzyloxyundec-2-yn-1-ol 
• 79950-42-8 2-allyl-3-hydroxy-benzaldehyde 
• 100-83-4 meta-hydroxybenzaldehyde 
• 40359-32-8 3-allyloxy-benzaldehyde 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 81846-19-7 treprostinil 
• 101692-02-8 (1R,2R,3aS,9aS)-2,3,3a,4,9,9a-hexahydro-1-((S)-3-hydroxyoctyl)-1H-cyclopenta[b]naphthalene-2,5-diol 
• 1355990-17-8 (1R,6S)-1-[-2-allyl-3-(4-methoxybenzyloxy)phenyl]-6-benzyloxyundec-2-yn-1-ol 
• 1355990-19-0 {(1R,6S)-1-[-2-allyl-3-(4-methoxybenzyloxy)phenyl]-6-benzyloxyundec-2-ynyloxy}-tert-butyl-dimethyl-silane 
• 1355990-21-4 (4R,9aS)-3-((S)-3-benzyloxyoctyl)-4-(tert-butyldimethylsilanyloxy)-8-(4-methoxybenzyloxy)-1,4,9,9a-tetrahydrocyclopenta[b]napthalen-2-one 
• 1355990-23-6 (3aS,9aS)-1-((S)-3-benzyloxyoctyl)-5-hydroxy-1,3,3a,4,9,9a-hexahydrobenz[f]inden-2-one 
• 1355990-25-8 (1R,2R,3aS,9aS)-1-((S)-3-benzyloxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalene-2,5-diol 
• 1355990-07-6 2-((1R,2R,3aS,9aS)-2-hydroxy-1-(S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalene-5-yloxylacetic acid ethyl ester 
• 81845-98-9 2-((1R,2R,3aS,9aS)-2-hydroxy-1-(S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalene-5-yloxylacetic acid methyl ester 

Relevant articles and documents

Synthesis Of Treprostinil And Intermediates Useful Therein

Treprostinil is prepared by a process which involves Pauson-Khan cyclization of an an alkene-substituted, alkyne-substituted benzene corresponding to formula: (I) where PMB represents para-methoxy benzyl protecting group and R1 and R2 are alcohol protecting groups. Following cyclization, the resulting compound can be subjected to several chemical trans-formations followed by alkylation, hydrolysis and salt formation to yield treprostinil sodium. The use of para-methoxybenzyl group as the phenolic protecting group confers several process advantages that result in simplified purification of the final product and improved yields.