1355993-09-7

Basic information

• Product Name: (R)-tert-butyl 1-(naphthalen-1-yl)ethyl(3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propyl)carbamate
• Synonyms: (R)-tert-butyl 1-(naphthalen-1-yl)ethyl(3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propyl)carbamate
• CAS NO: 1355993-09-7
• Molecular Weight: 515.501
• Mol File: 1355993-09-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-tert-butyl 1-(naphthalen-1-yl)ethyl(3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-tert-butyl 1-(naphthalen-1-yl)ethyl(3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propyl)carbamate(1355993-09-7)
• EPA Substance Registry System: (R)-tert-butyl 1-(naphthalen-1-yl)ethyl(3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propyl)carbamate(1355993-09-7)

Safety Data

• Hazardous Substances Data: 1355993-09-7(Hazardous Substances Data)

Upstream product

• 61220-44-8 3-(3-chlorophenyl)propyl 4-methylbenzenesulfonate 
• 1866-38-2 3-chlorocinnamic acid 
• 21640-48-2 3-chlorohydrocinnamic acid 
• 22991-03-3 3-(3-chlorophenyl)propanol 
• 1355993-08-6 (R)-tert-butyl-3-(3-chlorophenyl)propyl(1-(naphthalen-1-yl)-ethyl)carbamate 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 1355993-10-0 (R)-3-(3-((tert-butoxycarbonyl)(1-(naphthalen-1-yl)ethyl)amino)propyl)phenylboronic acid 
• 1204313-91-6 (R)-tert-butyl (1-(naphthalen-1-yl)ethyl)(3-(3-(trifluoromethyl)phenyl)propyl)carbamate 

Relevant articles and documents

Copper-catalyzed oxidative trifluoromethylation of terminal alkynes and aryl boronic acids using (trifluoromethyl)trimethylsilane

Trifluoromethylated acetylenes and arenes are widely applicable in the synthesis of pharmaceuticals and agrochemicals. In 2010, our group has reported the copper-mediated oxidative trifluomethylation of terminal alkynes and aryl boronic acids. This method allows a wide range of functional group tolerant trifluoromethylated acetylenes and arenes to be easily prepared. After the preliminary mechanistic studies of the oxidative trifluoromethylation of terminal alkyne, an efficient copper-catalyzed oxidative trifluoromethylation of terminal alkynes and aryl boronic acids has been developed. The catalytic protocol is successfully achieved by adding both the substrate and a portion of CF3TMS slowly using a syringe pump to the reaction mixture.