61220-44-8

Upstream product

• 22991-03-3 3-(3-chlorophenyl)propanol 
• 98-59-9 p-toluenesulfonyl chloride 
• 21640-48-2 3-chlorohydrocinnamic acid 
• 1866-38-2 3-chlorocinnamic acid 

Downstream Products

• 1355993-09-7 (R)-tert-butyl 1-(naphthalen-1-yl)ethyl(3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propyl)carbamate 
• 1355993-10-0 (R)-3-(3-((tert-butoxycarbonyl)(1-(naphthalen-1-yl)ethyl)amino)propyl)phenylboronic acid 
• 1204313-91-6 (R)-tert-butyl (1-(naphthalen-1-yl)ethyl)(3-(3-(trifluoromethyl)phenyl)propyl)carbamate 
• 1355993-08-6 (R)-tert-butyl-3-(3-chlorophenyl)propyl(1-(naphthalen-1-yl)-ethyl)carbamate 
• 78573-30-5 ethyl 3-(3-chlorophenyl)propylmalonate 

Relevant academic research and scientific papers

Copper-catalyzed oxidative trifluoromethylation of terminal alkynes and aryl boronic acids using (trifluoromethyl)trimethylsilane

Trifluoromethylated acetylenes and arenes are widely applicable in the synthesis of pharmaceuticals and agrochemicals. In 2010, our group has reported the copper-mediated oxidative trifluomethylation of terminal alkynes and aryl boronic acids. This method allows a wide range of functional group tolerant trifluoromethylated acetylenes and arenes to be easily prepared. After the preliminary mechanistic studies of the oxidative trifluoromethylation of terminal alkyne, an efficient copper-catalyzed oxidative trifluoromethylation of terminal alkynes and aryl boronic acids has been developed. The catalytic protocol is successfully achieved by adding both the substrate and a portion of CF3TMS slowly using a syringe pump to the reaction mixture.

Substituted oxiranecarboxylic acids, their use and medicaments containing them

Substituted oxiranecarboxylic acids of the formula STR1 wherein R1 denotes a hydrogen atom (--H), a halogen atom, a hydroxylroup, a lower alkyl group, a lower alkoxy group or a trifluoromethyl group, R2 has one of the meanings of Rs