1356145-18-0

Basic information

• Product Name: N,2-dimethyl-N'-((7-methylpyrazolo[1,5-a]pyridin-3-yl)methylene)-5-nitrobenzenesulfonohydrazide
• Synonyms: N,2-dimethyl-N'-((7-methylpyrazolo[1,5-a]pyridin-3-yl)methylene)-5-nitrobenzenesulfonohydrazide
• CAS NO: 1356145-18-0
• Molecular Weight: 387.419
• Mol File: 1356145-18-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N,2-dimethyl-N'-((7-methylpyrazolo[1,5-a]pyridin-3-yl)methylene)-5-nitrobenzenesulfonohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: N,2-dimethyl-N'-((7-methylpyrazolo[1,5-a]pyridin-3-yl)methylene)-5-nitrobenzenesulfonohydrazide(1356145-18-0)
• EPA Substance Registry System: N,2-dimethyl-N'-((7-methylpyrazolo[1,5-a]pyridin-3-yl)methylene)-5-nitrobenzenesulfonohydrazide(1356145-18-0)

Safety Data

• Hazardous Substances Data: 1356145-18-0(Hazardous Substances Data)

Upstream product

• 109-06-8 α-picoline 
• 121-02-8 2-methyl-5-nitrobenzene-1-sulfonyl chloride 
• 1356144-52-9 7-methylpyrazolo[1,5-a]pyridine-3-carbaldehyde 
• 16205-50-8 7-methylpyrazolo<1,5-a>pyridine 
• 16205-45-1 ethyl 7-methylpyrazolo[1,5-a]pyridine-3-carboxylate 

Relevant articles and documents

Discovery of pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors

We have made a novel series of pyrazolo[1,5-a]pyridines as PI3 kinase inhibitors, and demonstrated their selectivity for the p110α isoform over the other Class Ia PI3 kinases. We investigated the SAR around the pyrazolo[1,5-a]pyridine ring system, and found compound 5x to be a particularly potent example (p110α IC50 0.9 nM). This compound inhibits cell proliferation and phosphorylation of Akt/PKB, a downstream marker of PI3 kinase activity, and showed in vivo activity in an HCT-116 human xenograft model.