16205-45-1

Basic information

• Product Name: 7-METHYL-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 7-METHYL-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER;Ethyl 7-methylpyrazolo[1,5-a]pyridine-3-carboxylate;ethyl 7-MethylH-pyrazolo[1,5-a]pyridine-3-carboxylate
• CAS NO: 16205-45-1
• Molecular Formula: C11H12N2O2
• Molecular Weight: 204.23
• Product Categories: Building Blocks;Pyrazolo[x,x-y]pyridine
• Mol File: 16205-45-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.19g/cm³
• Refractive Index: 1.584
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 7-METHYL-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 7-METHYL-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER(16205-45-1)
• EPA Substance Registry System: 7-METHYL-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER(16205-45-1)

Safety Data

• Hazardous Substances Data: 16205-45-1(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 33, p. 2062, 1968 DOI: 10.1021/jo01269a075

InChI:InChI=1/C11H12N2O2/c1-3-15-11(14)9-7-12-13-8(2)5-4-6-10(9)13/h4-7H,3H2,1-2H3

Upstream product

• 109-06-8 α-picoline 
• 623-47-2 propynoic acid ethyl ester 

Downstream Products

• 1356145-18-0 N,2-dimethyl-N'-((7-methylpyrazolo[1,5-a]pyridin-3-yl)methylene)-5-nitrobenzenesulfonohydrazide 

Relevant articles and documents

Discovery of pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors

We have made a novel series of pyrazolo[1,5-a]pyridines as PI3 kinase inhibitors, and demonstrated their selectivity for the p110α isoform over the other Class Ia PI3 kinases. We investigated the SAR around the pyrazolo[1,5-a]pyridine ring system, and found compound 5x to be a particularly potent example (p110α IC50 0.9 nM). This compound inhibits cell proliferation and phosphorylation of Akt/PKB, a downstream marker of PI3 kinase activity, and showed in vivo activity in an HCT-116 human xenograft model.