1356151-85-3

Basic information

• Product Name: C₂₂H₂₄O₈
• CAS NO: 1356151-85-3
• Molecular Weight: 416.428
• Mol File: 1356151-85-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₄O₈(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₄O₈(1356151-85-3)
• EPA Substance Registry System: C₂₂H₂₄O₈(1356151-85-3)

Safety Data

• Hazardous Substances Data: 1356151-85-3(Hazardous Substances Data)

Upstream product

• 138456-91-4 6,7-O,O-demethylene-4'-O-demethylepipodophyllotoxin 
• 74-88-4 methyl iodide 
• 6559-91-7 4'-demethylepipodophyllotoxin 

Relevant articles and documents

Synthesis and evaluation of novel podophyllotoxin analogs

Because prior studies have shown inconsistency between structure-activity relationships for podophyllotoxin derivatives as topoisomerase II inhibitors and cytotoxic agents, eight novel podophyllotoxin analogs were synthesized to further explore the effects of structural variations on both A and D rings on activity. The new compounds contain a 4,5-dimethoxy substituted A ring and opened D-ring variants and were prepared by appropriate functional and stereochemical operations at the methylenedioxy group, C7, C8, and C8′. Four compounds (15, 18, 21 and 22) demonstrated noticeable inhibitory activity against A549, DU145, KB and KBvin tumor cells, and the most active compound 18 showed IC50 values less than 10 μg/mL.