1356445-91-4

Basic information

• Product Name: (RS)-3-hydroxy-N-methoxy-N-methyl-4,4,4-triphenylbutanamide
• Synonyms: (RS)-3-hydroxy-N-methoxy-N-methyl-4,4,4-triphenylbutanamide
• CAS NO: 1356445-91-4
• Molecular Weight: 375.467
• Mol File: 1356445-91-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (RS)-3-hydroxy-N-methoxy-N-methyl-4,4,4-triphenylbutanamide(CAS DataBase Reference)
• NIST Chemistry Reference: (RS)-3-hydroxy-N-methoxy-N-methyl-4,4,4-triphenylbutanamide(1356445-91-4)
• EPA Substance Registry System: (RS)-3-hydroxy-N-methoxy-N-methyl-4,4,4-triphenylbutanamide(1356445-91-4)

Safety Data

• Hazardous Substances Data: 1356445-91-4(Hazardous Substances Data)

Upstream product

• 42365-04-8 triphenylacetaldehyde 
• 78191-00-1 N-Methoxy-N-methylacetamide 

Downstream Products

• 1356445-92-5 (RS)-3-(tert-butyldimethylsilyloxy)-N-methoxy-N-methyl-4,4,4-triphenylbutanamide 
• 1356445-93-6 C₄₁H₅₇BO₂Si 
• 1356445-82-3 (RS)-4-(tert-butyldimethylsilyloxy)-5,5,5-triphenylpentan-2-one 

Relevant articles and documents

The role of β-bulky substituents in aldol reactions of boron enolates of methylketones with aldehydes: Experimental and theoretical studies by DFT analysis

In this work, we show the influence of the volume of the β-substituents on the levels of 1,5-stereoselectivities of aldol reactions of boron enolates generated from β-alkoxy methylketones with aldehydes. Excellent levels of 1,5-syn stereoinduction were obtained when the β-protecting group is a silicon ether. This remarkable selectivity is attributed to the volume of the β-bulky substituent of the corresponding boron enolate. We have investigated a stereochemical model using DFT analysis to rationalize the sense of 1,5-syn stereoselectivities of β-alkyl-β- alkoxy methylketones.