1356453-75-2

Upstream product

• 917-92-0 3,3-Dimethylbut-1-yne 
• 7311-63-9 5-bromothiophene-2-carboxylic acid 
• 1263098-95-8 5-(3,3-Dimethyl-but-1-ynyl)-thiophene-2-carboxylic acid 
• 1296689-53-6 (S)-6-cyclohexylpiperidin-2-one 
• 1356457-38-9 3-((S)-2-cyclohexyl-6-oxopiperidin-1-yl)-5-(3,3-dimethylbut-1-ynyl)thiophene-2carboxylic acid methyl ester 
• 1355039-59-6 methyl 3-bromo-5-(3,3-dimethylbut-1-yn-1-yl)thiophene-2-carboxylate 
• 1356457-37-8 (S)-5-cyclohexyl-5-((S)-1-phenylethylamino)pentanoic acid ethyl ester 
• 16076-61-2 ethyl 5-cyclohexyl-5-oxopentanoate 
• 1356457-15-2 3-bromo-5-(3,3-dimethylbut-1-ynyl)thiophene-2-carboxylic acid 

Relevant academic research and scientific papers

Design and synthesis of lactam-thiophene carboxylic acids as potent hepatitis C virus polymerase inhibitors

Herein we report the successful incorporation of a lactam as an amide replacement in the design of hepatitis C virus NS5B Site II thiophene carboxylic acid inhibitors. Optimizing potency in a replicon assay and minimizing potential risk for CYP3A4 induction led to the discovery of inhibitor 22a. This lead compound has a favorable pharmacokinetic profile in rats and dogs.

2,3,5-TRISUBSTITUTED THIOPHENE COMPOUNDS AND USES THEREOF

The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.