1356459-40-9Relevant academic research and scientific papers
How O-substitution of sialyl donors affects their stereoselectivity
Premathilake, Hemali D.,Gobble, Chase P.,Pornsuriyasak, Papapida,Hardimon, Tramaine,Demchenko, Alexei V.,De Meo, Cristina
supporting information; experimental part, p. 1126 - 1129 (2012/03/27)
The profound effect of substituents at C-5 of glycosyl sialosides on their stereoselectivity is well-known although the exact nature of this effect is somewhat less understood. Presented herein is a comparative study of a range of novel sialyl donors with various O-substituents. It is demonstrated that O-substituents at C-4 and C-7 may also have a significant effect on the reactivity of sialyl donors and on the stereoselectivity of chemical sialylation.
