1356470-27-3

Basic information

• Product Name: (E)-N,3-di-p-tolylacrylamide
• Synonyms: (E)-N,3-di-p-tolylacrylamide
• CAS NO: 1356470-27-3
• Molecular Weight: 251.328
• Mol File: 1356470-27-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (E)-N,3-di-p-tolylacrylamide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N,3-di-p-tolylacrylamide(1356470-27-3)
• EPA Substance Registry System: (E)-N,3-di-p-tolylacrylamide(1356470-27-3)

Safety Data

• Hazardous Substances Data: 1356470-27-3(Hazardous Substances Data)

Upstream product

• 1866-39-3 4-methylcinnamic acid 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 99-99-0 1-methyl-4-nitrobenzene 
• 13939-06-5 molybdenum hexacarbonyl 
• 166824-04-0 4-methyl-α-[(1E)-2-(4-methylphenyl)ethenyl]benzenemethanol 
• 1228050-59-6 C₁₇H₁₈ 
• 1092381-54-8 (E)-4,4′-(prop-1-ene-1,3-diyl)bis(methylbenzene) 

Relevant articles and documents

Direct Amidation of Carboxylic Acids with Nitroarenes

N-Aryl amides are an important class of compounds in pharmaceutical and agrochemical chemistry. Rapid and low-cost synthesis of N-aryl amides remains in high demand. Herein, we disclose an operationally simple process to access N-aryl amides directly from readily available nitroarenes and carboxylic acids as coupling substrates. This method involves the in situ activation of carboxylic acids to acyloxyphosphonium salt for one-pot amidation, without the need for isolation of the corresponding synthetic intermediates. Furthermore, the ease of preparation and workup allow the quick and efficient synthesis of a wide range of N-aryl amides, including several amide-based druglike and agrochemical molecules.

Copper-catalyzed direct transformation of secondary allylic and benzylic alcohols into azides and amides: An efficient utility of azide as a nitrogen source

A mild and convenient method for the synthesis of amides has been explored by using secondary alcohols, Cu(ClO4)2·6H2O as a catalyst, and trimethylsilyl azide (TMSN3) as a nitrogen source in the presence of 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) at ambient temperature. This method has been successfully adapted to the preparation of azides directly from their corresponding alcohols and offers excellent chemoselectivity in the formation of ω-halo azides and the azidation of allylic alcohols in the presence of a benzyl alcohol moiety. In addition, this strategy provides an opportunity to synthesize azides that can serve as precursors to β-amino acids. A mild and convenient method for the synthesis of amides has been explored by using secondary alcohols, Cu(ClO4)2·6H2O as a catalyst, and trimethylsilyl azide (TMSN3) as a nitrogen source in the presence of 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) at ambient temperature. This method has also been adapted to the preparation of azides directly from their corresponding alcohols.

Iron-catalyzed C-H and C-C bond cleavage: A direct approach to amides from simple hydrocarbons

Something functional: The title reaction proceeds in the presence of azide and water to deliver amides in high yields, and it can be used in a ring-expansion strategy to generate lactams. A mechanism is proposed based on experimental results. This reaction offers a new approach to functionalizing simple and readily available hydrocarbons. DDQ=2,3-dichloro-5,6-dicyano-1,4- benzoquinone. Copyright