1356485-86-3Relevant academic research and scientific papers
Structure-activity relationships of cyanoquinolines with corrector-potentiator activity in Δf508 cystic fibrosis transmembrane conductance regulator protein
Knapp, John M.,Wood, Alex B.,Phuan, Puay-Wah,Lodewyk, Michael W.,Tantillo, Dean J.,Verkman,Kurth, Mark J.
, p. 1242 - 1251 (2012/04/04)
Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. The most common CF-causing mutation, ΔF508-CFTR, produces CFTR loss-of-function by impairing its cellular targeting to the plas
