1356486-34-4Relevant academic research and scientific papers
Synthesis of 3-Aryl-2-(trifluoromethyl)indoles via Copper-Catalyzed Hydroarylation and Subsequent Cadogan Cyclization
Yamamoto, Yoshishiko,Ohkubo, Erina,Shibuya, Masatoshi
, p. 1747 - 1751 (2017)
The copper-catalyzed hydroarylation of (trifluoromethyl)alkynes with (o-nitrophenyl)boronic acids selectively afforded trisubstituted (trifluoromethyl)alkenes bearing an o-nitrophenyl group. The obtained hydroarylation products were converted into 3-aryl-2-(trifluoromethyl)indoles in high yields via molybdenum-catalyzed Cadogan cyclization. Similarly, the hydroarylation product prepared from (o-nitrophenyl)(trifluoromethyl)alkyne and (p-anisyl)boronic acid also underwent Cadogan cyclization, albeit with a longer reaction time, affording the desired indole product in a high yield. (Figure presented.).
An improved copper-mediated oxidative trifluoromethylation of terminal alkynes
Zhang, Ke,Qiu, Xiao-Long,Huang, Yangen,Qing, Feng-Ling
supporting information; experimental part, p. 58 - 61 (2012/01/15)
An improved method for the efficient copper-mediated trifluoromethylation of terminal alkynes has been developed. This protocol highlights the convenient access to a variety of aryl-substituted trifluoromethylated alkynes by oxidative trifluoromethylation
