135654-20-5Relevant academic research and scientific papers
Non-steroidal anti-inflammatory agents. Part 23: Synthesis and pharmacological activity of enaminones which inhibit both bovine cyclooxygenase and 5-lipoxygenase
Dannhardt,Bauer,Nowe
, p. 256 - 263 (2007/10/03)
The synthesis and stereochemical characteristics of pyrrolidino-, isoquinolino- and indolo-enaminones 2-11 are reported. The inhibition of cyclooxygenase was determined in a bovine thrombocyte intact cell assay and that of 5-lipoxygenase using intact bovine polymorphonuclear leucocytes. Except compound 2c′ which is a well-balanced dual inhibitor of both enzymes, all other enaminone derivatives are weak inhibitors of both cyclooxygenase and 5-lipoxygenase. Structure-activity relationships of the enaminones in relation to known anti-inflammatory drugs are discussed. Johann Ambrosius Barth 1998.
SYNTHESIS OF SOME NOVEL α,β-ETHYLENIC SULFONES
Reddy, M. V. Ramana,Vijayalakshmi, S.,Reddy, D. Bhaskar,Reddy, P. V. Ramana
, p. 209 - 214 (2007/10/02)
Novel unsaturated sulfones E-alkoxy/carbamoyl benzyl styryl sulfones (VI) and E-4(N-benzylcarbamoyl)benzyl styryl sulfones (IX) have been prepared by the Knoevenagel condensation of alkoxy/carbamoyl benzylsulfonylacetic acid (V) and 4-carboxybenzylsulfonylacetic acid (VIII) with araldehydes.The E-geometry of these compounds has been assigned based on IR and 1H NMR spectral data. Key words: Configuration, Knoevenagel condensation, sulfonylacetic acids, unsaturated sulfones.
