1356599-86-4

Upstream product

• 623-05-2 (4-hydroxyphenyl)methanol 
• 31376-92-8 (1E,1Z)-2-bromo-N-methoxy-1-phenylethanimine 
• 142533-52-6 (Z)-2-bromo-1-phenylethanone O-methyl oxime 

Downstream Products

• 1356600-22-0 4-[(4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]benzaldehyde 
• 1356602-50-0 4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]benzaldehyde 
• 1356601-66-5 methyl 3-cyano-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate 
• 1356598-72-5 3-cyano-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid 
• 1431511-37-3 (1Z)-2-[4-(bromomethyl)phenoxy]-N-methoxy-1-phenylethanimine 
• 1356603-00-3 ethyl 3-cyano-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate 
• 1356598-74-7 sodium 3-cyano-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate 
• 1356598-73-6 3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}-3-(1,2-oxazol-3-yl)propanoic acid 
• 1356600-16-2 methyl 3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}-3-(1,2-oxazol-3-yl)propanoate 
• 1356598-68-9 3-cyano-3-[4-({3-[(E,Z)-(methoxyimino)(phenyl)methyl]benzyl}oxy)phenyl]propanoic acid 
• 1356602-59-9 ethyl 3-hydroxy-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate 
• 1356602-57-7 ethyl 3-hydroxy-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}-2-(phenylsulfanyl)propanoate 
• 1356602-55-5 ethyl 5-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}-2-oxo-1,3-dioxolane-4-carboxylate 
• 1356602-53-3 ethyl 2,3-dihydroxy-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate 

Relevant academic research and scientific papers

PROCESS FOR THE PREPARATION OF AN ARYL OXIME AND SALTS THEREOF

The invention relates to a process for the preparation of 3-cyano-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl] oxy} benzyl) oxy] phenyl} propanoic acid or salts thereof. In one form, the invention relates to the process for the preparation of (-)-3-cyano-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid and conversion of the (-)-enantiomer to the sodium salt, sodium 3-cyano-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy] phenyl}propanoate.

AGONISTS OF GPR40

The present invention relates to compounds that have the ability to modulate the activity of GPR40 and are there-fore useful in the treatment of GPR40 related disorders. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders related to GPR40 activity.