1356690-40-8Relevant articles and documents
Copper(i) catalyzed asymmetric 1,2-addition of Grignard reagents to α-methyl substituted α,β-unsaturated ketones
Madduri, Ashoka V. R.,Minnaard, Adriaan J.,Harutyunyan, Syuzanna R.
supporting information; experimental part, p. 1478 - 1480 (2012/02/16)
The first catalytic enantioselective 1,2-addition of Grignard reagents to ketones is presented. This additive-free copper(i) catalyzed 1,2-addition provides chiral allylic tertiary alcohols with an er of up to 98:2 and excellent yields due to the complete shift of overwhelming 1,4-selectivity of copper(i)-catalysts towards 1,2-selectivity in the addition reaction to enones.
