1356835-83-0

Basic information

• Product Name: C₁₁H₁₅ClN₂O₂
• CAS NO: 1356835-83-0
• Molecular Weight: 242.705
• Mol File: 1356835-83-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₁H₁₅ClN₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₁H₁₅ClN₂O₂(1356835-83-0)
• EPA Substance Registry System: C₁₁H₁₅ClN₂O₂(1356835-83-0)

Safety Data

• Hazardous Substances Data: 1356835-83-0(Hazardous Substances Data)

Upstream product

• 40397-95-3 2-chloro-1-isocyanato-4-nitro-benzene 
• 71-36-3 butan-1-ol 

Relevant articles and documents

Synthesis and structure-activity relationships of (aryloxy)quinazoline ureas as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors

In our continuing search for medicinal agents to treat proliferative diseases, quinazoline derivatives were synthesized and evaluated pharmacologically as epithelial growth factor receptor and vascular endothelial growth factor receptor 2 (VEGFR-2) tyrosine kinase inhibitors. A quantitative structure-activity relationship analysis was conducted to rationalize the structure-activity relationship and to predict how similar the inhibitor-binding profiles of two protein kinases are likely to be on the basis of the docking of lead coumpounds into the ATP-binding site. This model was used to direct the synthesis of new compounds. A series of N-(aromatic)-N′-{4-[(6,7- dimethoxyquinazolin-4-yl)oxy]phenyl}urea were identified as potent and selective inhibitors of the tyrosine kinase activity of VEGFR-2 (fetal liver kinase 1, kinase insert domain-containing receptor). An efficient route was developed that enabled the synthesis of a wide variety of analogues with substitution on several positions of the template. Substitution of diarylurea, competitive with ATP, afforded several analogues with low nanomolar inhibition of enzymatic activity of VEGFR-2. In this paper, we describe the synthesis, structure-activity relationships, and pharmacological characterization of the series.