40397-95-3 Usage
Uses
Used in Pharmaceutical Industry:
2-CHLORO-4-NITROPHENYL ISOCYANATE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its reactivity allows for the creation of new drug molecules with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2-CHLORO-4-NITROPHENYL ISOCYANATE is employed as a precursor in the development of pesticides and other agrochemical products, contributing to the production of effective solutions for crop protection.
Used in Dye Industry:
2-CHLORO-4-NITROPHENYL ISOCYANATE is utilized as a building block in the formulation of dyes, providing a range of color options for various applications, including textiles and other industrial processes.
Used in Polymer Industry:
As an isocyanate, 2-CHLORO-4-NITROPHENYL ISOCYANATE is used in the production of polyurethane polymers, which are versatile materials with applications in coatings, adhesives, and flexible foams.
Safety Precautions:
Due to its potential to cause irritation to the skin, eyes, and respiratory system, as well as its allergenic and sensitizing properties, 2-CHLORO-4-NITROPHENYL ISOCYANATE requires proper handling and safety measures. Workers should use appropriate personal protective equipment and follow established safety protocols when working with this chemical compound.
Check Digit Verification of cas no
The CAS Registry Mumber 40397-95-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,3,9 and 7 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 40397-95:
(7*4)+(6*0)+(5*3)+(4*9)+(3*7)+(2*9)+(1*5)=123
123 % 10 = 3
So 40397-95-3 is a valid CAS Registry Number.
InChI:InChI=1/C7H3ClN2O3/c8-6-3-5(10(12)13)1-2-7(6)9-4-11/h1-3H
40397-95-3Relevant academic research and scientific papers
Design, synthesis and antitumor activity of 4-aminoquinazoline derivatives targeting VEGFR-2 tyrosine kinase
Yu, Bing,Tang, Li-Da,Li, Yi-Liang,Song, Shu-Hui,Ji, Xiao-Liang,Lin, Mu-Sen,Wu, Chun-Fu
scheme or table, p. 110 - 114 (2012/02/16)
We report herein the design and synthesis of novel 4-aminoquinazoline derivatives based on the inhibitors of VEGFR-2 tyrosine kinases. The VEGFR-2 inhibitory activities of these newly synthesized compounds were also evaluated and compared with that of ZD6
Novel and efficient synthesis of 4-substituted-1,2,4-triazolidine-3,5- diones from anilines
Mallakpour, Shadpour,Rafiee, Zahra
, p. 1927 - 1934 (2008/02/04)
A simple and efficient three-step synthetic procedure for the preparation of 4-substituted phenyl derivatives of 1,2,4-triazolidindiones (urazoles), starting from anilines, has been developed. In this method, aniline derivatives were reacted with 4-nitrophenyl chloroformate to provide corresponding carbamate derivatives. In the second step, semicarbazide derivatives were prepared from these carbamates by reaction with ethyl carbazate. The cyclization reaction of corresponding semicarbazides furnished 1,2,4-triazolidindiones in high yields. Copyright Taylor & Francis Group, LLC.
