1356844-82-0

Basic information

• Product Name: C₂₁H₂₂F₂N₂O₇
• Synonyms: C₂₁H₂₂F₂N₂O₇
• CAS NO: 1356844-82-0
• Molecular Weight: 452.412
• Mol File: 1356844-82-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₂F₂N₂O₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₂F₂N₂O₇(1356844-82-0)
• EPA Substance Registry System: C₂₁H₂₂F₂N₂O₇(1356844-82-0)

Safety Data

• Hazardous Substances Data: 1356844-82-0(Hazardous Substances Data)

Upstream product

• 38818-50-7 4-chloro-3-nitro-benzoyl chloride 
• 55-10-7 4-hydroxy-3-methoxy-mandelic acid 
• 59320-12-6 N-butyl-(4-chloro-3-nitrophenyl)carboxamide 
• 1092718-57-4 methyl 2-(4-(4-(butylcarbamoyl)-2-nitrophenoxy)-3-methoxyphenyl)-2-hydroxyacetate 
• 1092718-61-0 2-(4-(4-(butylcarbamoyl)-2-nitrophenoxy)-3-methoxyphenyl)-2-hydroxyacetic acid 

Downstream Products

• 1356844-65-9 C₂₆H₂₄Cl₂F₂N₂O₇S 
• 1356844-83-1 C₂₁H₂₄F₂N₂O₅ 
• 1356844-84-2 C₂₇H₂₆Cl₂F₂N₂O₇S 

Relevant articles and documents

Optimization of phenylacetic acid derivatives for CRTH2 and DP selective antagonism

We have previously reported that optimization of a series of phenylacetic acid derivatives led to the discovery of CRTH2 and DP dual antagonists, such as AMG 009 and AMG 853. During the optimization process, we discovered that minor structural modifications also afforded potent and selective CRTH2 or DP antagonists. Here we report the structure-activity relationship that led to the discovery of selective CRTH2 antagonists such as 2 and 17, and selective DP antagonists, such as 4 and 5.