1356845-32-3 Usage
Uses
Used in Pharmaceutical Industry:
1-((4-chlorophenyl)ethynyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline is used as a potential starting compound for the development of new drugs. Its unique structure and potential pharmaceutical properties make it a promising candidate for further investigation and research in the field of medicinal chemistry.
Used in Chemical Biology Research:
1-((4-chlorophenyl)ethynyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline is used as a research tool in chemical biology to study its interactions with biological systems and to understand its potential applications in various biological processes. The presence of different functional groups in its structure allows for the possibility of exploring its activity against specific targets or pathways.
Used in Drug Design and Optimization:
1-((4-chlorophenyl)ethynyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline can be employed in the design and optimization of new drugs, particularly those targeting specific receptors or enzymes. Its structural features may provide a foundation for the development of more potent and selective drug candidates.
Used in Drug Synthesis:
1-((4-chlorophenyl)ethynyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline can be utilized as an intermediate or building block in the synthesis of more complex drug molecules. Its unique structure and functional groups may facilitate the creation of novel drug candidates with improved pharmacological properties.
Check Digit Verification of cas no
The CAS Registry Mumber 1356845-32-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,6,8,4 and 5 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1356845-32:
(9*1)+(8*3)+(7*5)+(6*6)+(5*8)+(4*4)+(3*5)+(2*3)+(1*2)=183
183 % 10 = 3
So 1356845-32-3 is a valid CAS Registry Number.
1356845-32-3Relevant academic research and scientific papers
Gold Catalyzed Photoredox C1-Alkynylation of N-Alkyl-1,2,3,4- tetrahydroisoquinolines by 1-Bromoalkynes with UVA LED Light
Zhao, Yichao,Jin, Jianwen,Chan, Philip Wai Hong
, p. 1313 - 1321 (2019/06/03)
A synthetic method that combines [Au2(m-dppm)2]Cl2 (dppm=bis(diphenylphosphanyl)methane) and UVA LED (LED=light emitting diode) light (365 nm) to catalyze the regioselective C1-alkynylation of N-alkyl-1,2,3,4-tetrahydroisoquinolines (THIQs) with alkynyl bromides is described. The reaction mechanism was delineated to involve a reductive quench pathway to generate the two posited radical species of the nitrogen-containing heterocycle and organic halide. In contrast, radical formation via an oxidative quench pathway was suggested to be operative in analogous control experiments with a 1-iodoalkyne. The usefulness of this carbon-carbon bond forming strategy was also exemplified by its application to the formal synthesis of the opioid analgesic drug methopholine and synthesis of a protoberberine alkaloid derivative.
C-1 alkynylation of N-methyltetrahydroisoquinolines through CDC: A direct access to phenethylisoquinoline alkaloids
Singh, Kamal Nain,Singh, Paramjit,Kaur, Amarjit,Singh, Pushpinder
, p. 760 - 764 (2012/07/02)
Direct cross-coupling between N-methyltetrahydroisoquinolines and alkynes using CuI-DEAD is presented. It affords the regioselective C-1-alkynylated products in good yield. This regio-selectivity is in contrast to the results reported earlier in the reaction of N,N-dimethylbenzyl amine where the N-methyl alkynylated product was formed exclusively or predominantly. The C-1-substituted propargylic isoquinolines were easily reduced to phenethylisoquinolines with Pd/C. This reaction sequence provides a short route to synthesize methopholine, homolaudanosine and other phenethylisoquinoline alkaloids. Georg Thieme Verlag Stuttgart · New York.
