180003-15-0

Basic information

• Product Name: metofoline
• Synonyms: metofoline
• CAS NO: 180003-15-0
• Molecular Weight: 345.869
• Mol File: 180003-15-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: metofoline(CAS DataBase Reference)
• NIST Chemistry Reference: metofoline(180003-15-0)
• EPA Substance Registry System: metofoline(180003-15-0)

Safety Data

• Hazardous Substances Data: 180003-15-0(Hazardous Substances Data)

Upstream product

• 873-73-4 4-n-chlorophenylacetylene 
• 1356845-32-3 1-((4-chlorophenyl)ethynyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 1615-02-7 p-chlorocinnamic acid 
• 31357-32-1 α,β-dibromo-p-chlorohydrocinnamic acid 
• 66482-29-9 1-(2-bromovinyl)-4-chlorobenzene 
• 104-88-1 4-chlorobenzaldehyde 
• 50-00-0 formaldehyd 
• 123279-36-7 (+/-)-1-(4-chlorophenyl)-2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)ethanol 
• 16620-96-5 2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 78373-75-8 bromure de dimethoxy-6,7 methyl-2 dihydro-3,4 isoquinoleinium 
• 36159-18-9 (4-chlorophenethyl)magnesium bromide 
• 4721-98-6 6,7-dimethoxy-1-methyl-3,4-dihydroisoquinoline 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 

Relevant articles and documents

Succinct Syntheses of Methopholine, (±)-Homolaudanosine, and (±)-Dysoxyline via Metal-free One-Pot Double Alkylation on 1-Methyl-3,4-dihydroisoquinolines

A mild one-pot and metal-free condition was discovered to implement two different alkyl groups chemoselectively on 1-methyl-3,4-dihydroisoquinoline (1-Me-DHIQ), one at the nitrogen another at the C1-methyl group. This chemistry is compatible with various DHIQs as well as alkyl halides. Application of this chemistry facilitated the concise syntheses of methopholine, (±)-homolaudanosine, and (±)-dysoxyline, requiring only two steps from 6,7-dimethoxy-1-Me-DHIQ.

Mild metal-free tandem α-alkylation/cyclization of N-benzyl carbamates with simple olefins

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