135689-72-4Relevant academic research and scientific papers
COMPOUND CONTAINING A NOVEL 4-ALKOXYPYRIMIDINE STRUCTURE AND MEDICINE CONTAINING SAME
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Page/Page column 28, (2013/02/27)
Disclosed is novel compound and medicinal formulation containing same, possessing both angiotensin II receptor blocking and PPARγ activation effect, of use as a medicine for prevention and/or treatment of hypertension, heart disease, angina pectoris, cerebrovascular disorder, cerebral circulatory disturbances, post-ischemic peripheral circulatory damage, renal disease, arteriosclerosis, inflammatory disorder, type 2 diabetes, diabetic complications, insulin resistance syndrome, syndrome X, metabolic syndrome and hyperinsulinaemia. Further disclosed is the general formula I (where one or both of R1 and R2 represent a C1-6 alkyl group, R3 represents a C1-6 alkyl group which may contain one or more substituent groups selected from group A, or a C3-8 cycloalkyl group which may contain one or more substituent groups selected from group B.) which represents the compound, and salts thereof, solvates thereof, and medicinal compositions containing any of these.
Synthesis and angiotensin II receptor antagonist activity of C-linked pyrimidine derivatives
Nicolai, E.,Cure, G.,Goyard, J.,Kirchner, M.,Teulon, J. M.,et al.
, p. 365 - 376 (2007/10/02)
The synthesis and pharmacological activity of nonpeptide angiotensin II (Ang II) receptor antagonists are presented.These 3-N-substituted pyrimidine 4(3H)-one and 4-O,N,S-substituted pyrimidine derivatives represent a series of C-linked biphenyl tetrazole
