135692-96-5Relevant academic research and scientific papers
Gossypol and Derivatives: A New Class of Aldose Reductase Inhibitors
Deck, Lorraine M.,Jagt, David L. Vander,Royer, Robert E.
, p. 3301 - 3305 (1991)
Gossypol and 17 derivatives were tested as inhibitors of aldose reductase from human placenta.Gossypol and a number of the derivatives were potent inhibitors.The order of inhibitory activity was interpreted in relation to the Kador-Sharpless pharmacophor model for the aldose reductase inhibitor site.The structural but not the electronic aspects of the model were found to apply to this series of compounds.
