Gossypol and Derivatives: A New Class of Aldose Reductase Inhibitors

Article abstract of DOI:10.1021/jm00115a021

Gossypol and 17 derivatives were tested as inhibitors of aldose reductase from human placenta.Gossypol and a number of the derivatives were potent inhibitors.The order of inhibitory activity was interpreted in relation to the Kador-Sharpless pharmacophor model for the aldose reductase inhibitor site.The structural but not the electronic aspects of the model were found to apply to this series of compounds.