Journal of Medicinal Chemistry p. 3301 - 3305 (1991)
Update date:2022-07-30
Topics:
Deck, Lorraine M.
Jagt, David L. Vander
Royer, Robert E.
Gossypol and 17 derivatives were tested as inhibitors of aldose reductase from human placenta.Gossypol and a number of the derivatives were potent inhibitors.The order of inhibitory activity was interpreted in relation to the Kador-Sharpless pharmacophor model for the aldose reductase inhibitor site.The structural but not the electronic aspects of the model were found to apply to this series of compounds.
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