135696-51-4 Usage
Uses
Used in Pharmaceutical Industry:
(5-Amino-1,2-dihydro-2-methyl-3-(phenylmethyl)pyrido(3,4-b)pyrazin-7-yl)carbamic acid ethyl ester is used as an anti-cancer agent for its ability to inhibit the c-Met enzyme, which is involved in the growth and spread of certain types of cancer cells. Its application aims to provide a therapeutic option for cancer treatment, particularly when used in combination with other anti-cancer drugs.
Used in Medical Research:
In the field of medical research, (5-Amino-1,2-dihydro-2-methyl-3-(phenylmethyl)pyrido(3,4-b)pyrazin-7-yl)carbamic acid ethyl ester is utilized for its potential in developing novel cancer treatment strategies. (5-Amino-1,2-dihydro-2-methyl-3-(phenylmethyl)pyrido(3,4-b)pyrazin-7-yl)carbamic acid ethyl ester is being actively investigated for its anti-cancer properties, with the goal of enhancing the understanding of its mechanisms of action and optimizing its therapeutic potential.
Used in Drug Development:
(5-Amino-1,2-dihydro-2-methyl-3-(phenylmethyl)pyrido(3,4-b)pyrazin-7-yl)carbamic acid ethyl ester is employed in drug development as a promising candidate for the creation of new pharmaceuticals targeting cancer. Its potent inhibition of the c-Met enzyme makes it a valuable asset in the development of targeted therapies for various types of cancer, with the potential to improve patient outcomes and survival rates.
Check Digit Verification of cas no
The CAS Registry Mumber 135696-51-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,5,6,9 and 6 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 135696-51:
(8*1)+(7*3)+(6*5)+(5*6)+(4*9)+(3*6)+(2*5)+(1*1)=154
154 % 10 = 4
So 135696-51-4 is a valid CAS Registry Number.
135696-51-4Relevant academic research and scientific papers
Antimitotic Agents. Alterations at the 2,3-Positions of Ethyl (5-Amino-1,2-dihydropyridopyrazin-7-yl)carbamates
Temple, Carroll,Rener, Gregory A.,Comber, Robert N.,Waud, William R.
, p. 3176 - 3181 (2007/10/02)
The reaction of ethyl (6-amino-4-chloro-5-nitropyridin-2-yl)carbamate (2) with α-amino ketone oximes gave 4-pyridine oximes 3, which were reductively cyclized to give a series of ethyl (1,2-dihydropyridopyrazin-7-yl)carbamates (6).In another approach, α-nitro ketones, α-oximino ketones, and α-nitro alcohols were reduced to give α-amino alcohols, which were reacted with 2 to give 4-pyridines (5).Oxidation of these alcohols with the chromium trioxide-pyridine reagent gave the corresponding ketones (4), which were also reductively cyclized to give 6.Structure-activity relationship studies indicated that alterations at the 2- and 3-positions of the pyrazine ring of 6 had a significant effect on cytotoxicity and the inhibition of mitosis in cultured lymphoid leukemia L1210 cells.Compounds that exhibited in vitro cytotoxicities at less than 1 nM showed the same level of in vivo activity, whereas the less potent compounds showed wide variations in their in vivo activity.
