62634-57-5Relevant academic research and scientific papers
A novel nitroaldol reaction catalyzed by rhodium complex in the presence of a silyl ketene acetal
Kiyooka, Syun-Ichi,Tsutsui, Takanori,Maeda, Hirofumi,Kaneko, Yuichi,Isobe, Kiyoshi
, p. 6531 - 6534 (1995)
A rhodium complex, [{Rh(C5Me5)Cl}2(μ-Cl)2], catalyzed smoothly the nitroaldol reaction of nitroethane with aldehydes in the presence of a silyl ketene acetal. This reaction is the first example of transition met
Synthesis of unsaturated silyl nitronates via the silylation of conjugated nitroalkenes
Khotyantseva, Elizaveta A.,Tabolin, Andrey A.,Novikov, Roman A.,Nelyubina, Yulia V.,Ioffe, Sema L.
supporting information, p. 3128 - 3131 (2018/07/13)
A new method for the synthesis of conjugated silyl nitronates from nitroalkenes is described. The procedure has wide substrate scope and is compatible with in situ generation of the substrates from 2-nitroalcohols or 2-chloro-nitroalkanes. A cascade transformation to give 3,4,5,6-tetrahydropyridine N-oxide derivatives was disclosed.
One-pot solid phase synthesis of (E)-nitroalkenes
Rokhum, Lalthazuala,Bez, Ghanashyam
, p. 5500 - 5504 (2013/09/23)
An efficient one-pot protocol for the synthesis of (E)-nitroalkenes by reaction of aldehydes and nitroalkanes in the presence of polymer-bound triphenylphosphine, iodine and imidazole is described. Although the reaction works with similar efficiency with triphenylphosphine and its polymer-bound version, easy removal of the unwanted polymer-bound triphenylphosphine oxide and its recovery as triphenylphosphine provide the edge for practical application of the method.
Antimitotic Agents. Alterations at the 2,3-Positions of Ethyl (5-Amino-1,2-dihydropyridopyrazin-7-yl)carbamates
Temple, Carroll,Rener, Gregory A.,Comber, Robert N.,Waud, William R.
, p. 3176 - 3181 (2007/10/02)
The reaction of ethyl (6-amino-4-chloro-5-nitropyridin-2-yl)carbamate (2) with α-amino ketone oximes gave 4-pyridine oximes 3, which were reductively cyclized to give a series of ethyl (1,2-dihydropyridopyrazin-7-yl)carbamates (6).In another approach, α-nitro ketones, α-oximino ketones, and α-nitro alcohols were reduced to give α-amino alcohols, which were reacted with 2 to give 4-pyridines (5).Oxidation of these alcohols with the chromium trioxide-pyridine reagent gave the corresponding ketones (4), which were also reductively cyclized to give 6.Structure-activity relationship studies indicated that alterations at the 2- and 3-positions of the pyrazine ring of 6 had a significant effect on cytotoxicity and the inhibition of mitosis in cultured lymphoid leukemia L1210 cells.Compounds that exhibited in vitro cytotoxicities at less than 1 nM showed the same level of in vivo activity, whereas the less potent compounds showed wide variations in their in vivo activity.
