1356962-92-9

Upstream product

• 7149-77-1 1,5-dichloro-2-methyl-4-nitrobenzene 
• 100777-46-6 1-chloro-5-methoxy-2-methyl-4-nitrobenzene 
• 172281-90-2 N,N-dimethylpiperidine-4-amine hydrochloride 

Downstream Products

• 1356963-03-5 1-(4-amino-5-methoxy-2-methylphenyl)-N,N-dimethylpiperidine-4-amine 

Relevant academic research and scientific papers

ARYL-PHOSPHORUS-OXYGEN COMPOUND AS EGFR KINASE INHIBITOR

Disclosed is a class of new aryl-phosphorus-oxygen compounds as shown in formula (I) as EGFR kinase inhibitors, and pharmaceutically acceptable salts thereof.

PYRIMIDINE DERIVATIVE AND USE THEREOF

The present invention provides a pyrimidine derivative and a use thereof. The pyrimidine derivative is the compound shown in formula I or a pharmaceutically acceptable salt, hydrate, solvate, metabolite or prodrug thereof, wherein, R1, R2, R3, R4 and R5 are, for example, as defined in the specification. The compound can act as an ALK inhibitor, and is for preparing an anti-tumor medicament for suppressing an anaplastic lymphoma kinase.

CHEMICAL COMPOUNDS

The present invention relates to compounds of Formula (I) and/or Formula (Ia): and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds inhibit ALK kinase activity, and thus may be used for the tr