172281-90-2

Basic information

• Product Name: N,N-dimethylpiperidin-4-amine
• Synonyms: EOS-62282
• CAS NO: 172281-90-2
• Molecular Formula: C7H17ClN2
• Molecular Weight: 164.68
• Mol File: 172281-90-2.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: N,N-dimethylpiperidin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dimethylpiperidin-4-amine(172281-90-2)
• EPA Substance Registry System: N,N-dimethylpiperidin-4-amine(172281-90-2)

Safety Data

• Hazardous Substances Data: 172281-90-2(Hazardous Substances Data)

Upstream product

• 412293-88-0 4-dimethylaminopiperidine-1-carboxylic acid tert-butyl ester 
• 4876-56-6 1-benzyl-N,N-dimethylpiperidin-4-amine dihydrochloride 

Downstream Products

• 211247-60-8 N,N-dimethyl-1-(4-nitrophenyl)piperidin-4-amine 
• 1089279-90-2 1-(3-methoxy-4-nitrophenyl)-N,N-dimethylpiperidine-4-amine 
• 1356962-92-9 1-(5-methoxy-2-methyl-4-nitrophenyl)-N,N-dimethylpiperidine-4-amine 
• 1124330-03-5 1-(3-ethoxy-4-nitrophenyl)-N,N-dimethylpiperidin-4-amine 
• 1251838-36-4 (4-(dimethylamino)piperidin-1-yl)(4-nitrophenyl)methanone hydrochloride 

Relevant articles and documents

Cheap, efficient, and scalable synthesis of 4-N,N-dimethylaminopiperidine

A short, convenient, high-yielding, and economical synthesis of 4-N,N-dimethylaminopiperidine is described. The key step is the palladium-catalyzed reductive amination of 4-piperidone. Copyright Taylor & Francis Group, LLC.

Gedatolisib intermediates for preparation of (by machine translation)

The invention belongs to the organic synthesis and bulk drug intermediate preparation field, in particular to a method for preparing Gedatolisib, key intermediate and a key intermediate in the preparation method. The nitrobenzene nitrile and dicyanodiamine polyisobutylene triazine cyclization, morpholine link guan huan, hydrogenation of nitro reduction to obtain 4 - (4, 6 - II morpholino - 1, 3, 5 - triazine - 2 - yl) aniline; 4 - oxo-piperidine - 1 - carboxylic acid tert-butyl and dimethylamine salt by addition, de-Boc protecting group, amide, hydrogenation of nitro reduction to get new compounds (4 - aminophenyl) (4 - (dimethyl amino) piperidine - 1 - yl) methyl ketone; adopts the one-pot synthesis, (4, 6 - II morpholino - 1, 3, 5 - triazine - 2 - yl) aniline and chloromethane acid ester after the reaction, then adding (4 - aminophenyl) (4 - (dimethyl amino) piperidine - 1 - yl) methanone, to finally obtain the Gedatolisib. This preparation method has the advantages of easy availability of raw materials, process is simple, easy to operate, high yield and low cost and the like. (by machine translation)

2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION

A 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine derivative represented by the generalformula (1): [Chemical formula 1] (1) or a pharmaceutically acceptable saltthereof. They are useful as a therapeutic/preventive agent for diabetes, diabeticnephropathy, or glomerulosclerosis.