1357078-03-5 Usage
Uses
Used in Chemical Research:
B-(2-Oxo-2H-1-benzopyran-7-yl)boronic Acid is used as a fluorescent probe for detecting and studying reactive oxygen and nitrogen species (RONS). Its application in this field is crucial for understanding the role of these species in various chemical reactions and processes.
Used in Biological Research:
In the field of biology, B-(2-Oxo-2H-1-benzopyran-7-yl)boronic Acid serves as a valuable tool for investigating the presence and effects of peroxynitrite and other RONS in biological systems. This can help researchers gain insights into the mechanisms underlying various diseases and conditions associated with oxidative stress and nitrosative stress.
Used in Environmental Monitoring:
B-(2-Oxo-2H-1-benzopyran-7-yl)boronic Acid can be employed as a sensor for monitoring the levels of reactive oxygen and nitrogen species in the environment. This application is particularly relevant for assessing air and water quality, as well as for studying the impact of pollution on ecosystems.
Used in Pharmaceutical Development:
The compound's reactivity with peroxynitrite and other RONS makes it a potential candidate for the development of new drugs targeting conditions related to oxidative and nitrosative stress. By understanding the interactions between B-(2-Oxo-2H-1-benzopyran-7-yl)boronic Acid and these reactive species, researchers can design more effective therapeutic agents for treating diseases associated with these stressors.
Check Digit Verification of cas no
The CAS Registry Mumber 1357078-03-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,7,0,7 and 8 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1357078-03:
(9*1)+(8*3)+(7*5)+(6*7)+(5*0)+(4*7)+(3*8)+(2*0)+(1*3)=165
165 % 10 = 5
So 1357078-03-5 is a valid CAS Registry Number.
1357078-03-5Relevant articles and documents
Peroxynitrite is the major species formed from different flux ratios of co-generated nitric oxide and superoxide: Direct reaction with boronate-based fluorescent probe
Zielonka, Jacek,Sikora, Adam,Joseph, Joy,Kalyanaraman, Balaraman
, p. 14210 - 14216 (2010)
There is much interest in the nitration and oxidation reaction mechanisms initiated by superoxide radical anion (O2.- ) and nitric oxide (.NO). It is well known that O2.- and .NOrapidly react to form a potent oxidant, peroxynitrite anion (ONOO-). However, indirect measurements with the existing probes (e.g. dihydrorhodamine) previously revealed a bell-shaped response to co-generated .NO and O2..- fluxes, with the maximal yield of the oxidation or nitration product occurring at a 1:1 ratio. These results raised doubts on the formation of ONOO- per se at various fluxes of .NO and O2..- Using a novel fluorogenic probe, coumarin-7-boronic acid, that reacts stoichiometrically and rapidly with ONOO- (k = 1.1 x 106 M-1s -1), we report that ONOO- formation increased linearly and began to plateau after reaching a 1:1 ratio of co-generated .NO and O2.- fluxes. We conclude that ONOO- is formed as the primary intermediate during the reaction between .NO and O2.- co-generated at different fluxes.
