135708-82-6Relevant articles and documents
Synthetic Studies toward Rapamycin: A Solution to a Problem in Chirality Merger through Use of the Ireland Reaction
Fisher, Matthew J.,Myers, Cheryl D.,Joglar, Jesus,Chen, Shu-Hui,Danishefsky, Samuel J.
, p. 5826 - 5834 (2007/10/02)
A program directed toward a total synthesis of rapamycin is described.This paper reports the synthesis of enoate 36, a fragment that would correspond to carbons 28-49 of rapamycin.The two building blocks required to reach 36 were allylic alcohol 5 and aci