135708-88-2

Upstream product

• 135708-79-1 (2R,3S,5S,6R)-1-Benzyloxy-2,6-dimethyl-oct-7-ene-3,5-diol 
• 135708-85-9 C₄₉H₈₄O₇Si₃ 
• 135708-86-0 C₄₉H₈₄O₇Si₃ 
• 135708-84-8 (3R,4S,6S,7R)-8-Benzyloxy-4,6-bis-(tert-butyl-dimethyl-silanyloxy)-3,7-dimethyl-octanoic acid (1S,5R,6S)-6-benzyloxy-5-methoxy-cyclohex-2-enyl ester 
• 135708-83-7 (3R,4S,6S,7R)-8-Benzyloxy-4,6-bis-(tert-butyl-dimethyl-silanyloxy)-3,7-dimethyl-octanoic acid 
• 135708-81-5 (3R,4S,6S,7R)-8-Benzyloxy-4,6-bis-(tert-butyl-dimethyl-silanyloxy)-3,7-dimethyl-octan-1-ol 
• 135708-82-6 (3R,4S,6S,7R)-8-Benzyloxy-4,6-bis-(tert-butyl-dimethyl-silanyloxy)-3,7-dimethyl-octanal 
• 135708-80-4 [(2R,3S,5S,6R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2,6-dimethyl-oct-7-enyloxymethyl]-benzene 
• 135708-77-9 (R)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-4-methyl-pentanal 
• 135708-75-7 [1-((R)-2-Benzyloxy-1-methyl-ethyl)-but-3-enyloxy]-tert-butyl-dimethyl-silane 
• 89046-67-3 (5R)-6-benzyloxy-5-methyl-4-hydroxyhex-1-ene 
• 135708-87-1 (3R,4S,6S,7R)-8-Benzyloxy-2-((1S,4R,5R)-4-benzyloxy-5-methoxy-cyclohex-2-enyl)-4,6-bis-(tert-butyl-dimethyl-silanyloxy)-3,7-dimethyl-octanoic acid 

Downstream Products

• 1027462-18-5 (4R,5S)-5-[(2S,3R)-4-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-3-methyl-butyl]-3-((1R,3R,4R)-4-benzyloxy-3-methoxy-cyclohexyl)-4-methyl-tetrahydro-furan-2-ol 
• 1027944-26-8 Formic acid (1S,3S,4R)-5-benzyloxy-1-[(S)-2-((1R,3R,4R)-4-benzyloxy-3-methoxy-cyclohexyl)-2-iodo-1-methyl-ethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-methyl-pentyl ester 

Relevant academic research and scientific papers

AN APPLICATION OF THE SUAREZ REACTION TO THE REGIOSPECIFIC AND STEREOSPECIFIC SYNTHESIS OF THE C28-C42 SEGMENT OF RAPAMYCIN

Specific lactonization of a TBS ether followed by iodinative scission of a γ-lactol are the key elements of a strategy for maintaining continuous chemical distinction between the latent C34 and C32 hydroxyl groups of starting material 3 en route to 14, the C28-C42 fragment of rapamycin.

Synthetic Studies toward Rapamycin: A Solution to a Problem in Chirality Merger through Use of the Ireland Reaction

A program directed toward a total synthesis of rapamycin is described.This paper reports the synthesis of enoate 36, a fragment that would correspond to carbons 28-49 of rapamycin.The two building blocks required to reach 36 were allylic alcohol 5 and aci