1357104-60-9

Basic information

• Product Name: C₃₇H₄₆N₂O₅
• CAS NO: 1357104-60-9
• Molecular Weight: 598.783
• Mol File: 1357104-60-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₇H₄₆N₂O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₇H₄₆N₂O₅(1357104-60-9)
• EPA Substance Registry System: C₃₇H₄₆N₂O₅(1357104-60-9)

Safety Data

• Hazardous Substances Data: 1357104-60-9(Hazardous Substances Data)

Upstream product

• 76375-91-2 (3R,3aS,4R,5R,7S,9R,9aR,12R)-5-hydroxy-3-methoxy-4,7,9,12-tetramethyl-7-vinyloctahydro-4,9a-propanocyclopenta[8]annulen-8(9H)-one 
• 1357104-52-9 C₁₅H₁₄N₂O 
• 193536-85-5 (3R,3aS,4R,SR,7S,9R,9aR,12R)-3-methoxy-4,7,9,12-tetramethyl-8-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl carbonochloridate 
• 1357104-47-2 C₂₃H₂₂N₂O₂ 
• 552330-86-6 5-bromoisoindolin-1-one 
• 76338-20-0 (3R,3aS,4R,5R,7S,9R,9aR,12R)-3-methoxy-4,7,9,12-tetramethyl-8-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-hydroxyacetate 

Downstream Products

• 1357104-66-5 C₃₆H₄₄N₂O₅ 

Relevant articles and documents

Design, synthesis, and structure-activity relationship studies of conformationally restricted mutilin 14-carbamates

We report herein the design, synthesis, and structure-activity relationship studies of conformationally restricted mutilin 14-carbamates based on the structure of SB-222734. The antibacterial activities of these newly synthesized compounds were also evaluated and compared with linezolid and retapamulin. Results showed that most of the target compounds exhibit good potency in inhibiting the growth of Gram-positive bacteria including Methicillin- susceptible Staphylococcus aureus MSSA (MIC: 0.0625-2 μg/mL), Methicillin-resistant S. aureus MRSA (MIC: 0.0625-2 μg/mL), Methicillin-susceptible Staphylococcus epidermidis MSSE (MIC: 0.0625-2 μg/mL), Methicillin-resistant S. epidermidis MRSE (MIC: 0.0625-2 μg/mL), and Streptococcus pneumonia (MIC: 0.0625-4 μg/mL). In particular, three remarkable compounds of this series (12l, 12m, and 21l) exhibited comparable in vitro antibacterial profiles to that of retapamulin.