1357162-38-9

Basic information

• Product Name: C₂₁H₂₀N₂O₄
• CAS NO: 1357162-38-9
• Molecular Weight: 364.401
• Mol File: 1357162-38-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₀N₂O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₀N₂O₄(1357162-38-9)
• EPA Substance Registry System: C₂₁H₂₀N₂O₄(1357162-38-9)

Safety Data

• Hazardous Substances Data: 1357162-38-9(Hazardous Substances Data)

Upstream product

• 20033-99-2 (5-methoxy-1H-benzimidazole-2-yl)-methanol 
• 102-51-2 4-methoxy-1,2-phenylenediamine 
• 68426-83-5 (5-methoxy-1-methyl-1H-benzo[d]imidazol-2-yl)methanol 

Relevant articles and documents

Synthesis of substituted benzimidazolyl curcumin mimics and their anticancer activity

A novel curcumin mimic library (14a-14h and 15a-15h) possessing variously substituted benzimidazole groups was synthesized through the aldol reaction of (E)-4-(4-hydroxy-3-methoxyphenyl)but-3-en-2-one (7) or (E)-4-(3-hydroxy-4- methoxyphenyl)but-3-en-2-one (13) with diversely substituted benzimidazolyl-2-carbaldehyde (12a-12h). The MTT assay of the cancer cells MCF-7, SH-SY5Y, HEP-G2, and H460 showed that compound 14c with IC50 of 1.0 and 1.9 μM has a strong inhibitory effect on the growth of SH-SY5Y and Hep-G2 cells, respectively, and that compound 15h with IC50 of 1.9 μM has a strong inhibitory effect on the growth of MCF-7 cancer cells.