135734-22-4

Upstream product

• 100-39-0 benzyl bromide 
• 135708-79-1 (2R,3S,5S,6R)-1-Benzyloxy-2,6-dimethyl-oct-7-ene-3,5-diol 
• 89046-67-3 (5R)-6-benzyloxy-5-methyl-4-hydroxyhex-1-ene 
• 135708-75-7 [1-((R)-2-Benzyloxy-1-methyl-ethyl)-but-3-enyloxy]-tert-butyl-dimethyl-silane 
• 135708-77-9 (R)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-4-methyl-pentanal 

Relevant academic research and scientific papers

Synthetic Studies toward Rapamycin: A Solution to a Problem in Chirality Merger through Use of the Ireland Reaction

A program directed toward a total synthesis of rapamycin is described.This paper reports the synthesis of enoate 36, a fragment that would correspond to carbons 28-49 of rapamycin.The two building blocks required to reach 36 were allylic alcohol 5 and aci