1357378-64-3

Basic information

• Product Name: 2‐(4‐(methylthio)phenyl)benzo[d]oxazole
• Synonyms: 2‐(4‐(methylthio)phenyl)benzo[d]oxazole
• CAS NO: 1357378-64-3
• Molecular Weight: 241.313
• Mol File: 1357378-64-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2‐(4‐(methylthio)phenyl)benzo[d]oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2‐(4‐(methylthio)phenyl)benzo[d]oxazole(1357378-64-3)
• EPA Substance Registry System: 2‐(4‐(methylthio)phenyl)benzo[d]oxazole(1357378-64-3)

Safety Data

• Hazardous Substances Data: 1357378-64-3(Hazardous Substances Data)

Upstream product

• 104-95-0 (4-bromophenyl)thioanisole 
• 90005-49-5 4-(methylthio)benzamide 
• 583-53-9 2,3-dibromobenzene 
• 95-55-6 2-amino-phenol 
• 3446-89-7 4-(Methylthio)benzaldehyde 
• 1492192-84-3 C₁₄H₁₂BrNOS 
• 3446-90-0 4-(methylthio)benzyl alcohol 

Relevant articles and documents

Continuous flow/waste-minimized synthesis of benzoxazoles catalysed by heterogeneous manganese systems

Herein, we present our results on the development of a waste minimized protocol for the synthesis of 2-arylbenzoxazoles in continuous flow. Manganese-based heterogeneous catalysts were used in combination with cyclopentylmethyl ether as an environmentally friendly and safe reaction medium. The use of oxygen promotes the oxidative process ensuring at the same time a complete regeneration of the catalyst adopting a flow configuration which does not include the use of an additional mechanical pump. These features allowed for a faster synthesis compared to batch procedures with minimal metal leaching.

Synthesis and in vitro antibacterial and antifungal activities of benzoxazole derivatives

The in vitro antibacterial and antifungal activities of twenty-nine (29) benzoxazole derivatives were tested against fifteen Gram-positive and sixteen Gram-negative strains. Out of the twenty-nine compounds, eighteen compounds 3-5, 7-9, 11-13, 15-25 showed a broad range of activity against tested Gram-positive microorganisms, whereas rest of the compounds 6, 10, 14 and 26-31 were found to be completely inactive against all the tested strains of Gram-positive bacteria. Five compounds 8, 11-13, and 15 showed activities against Gram-negative strains whereas the rest were devoid of any activity. Twenty-one (21) out of twenty-nine (29) compounds possessed antifungal activity. The structures of the synthetic compounds were confirmed by IR, EIMS and 1HNMR spectral data.