1357485-73-4

Basic information

• Product Name: (2S,3S)-1-(4-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutylamino)benzyl) 4-benzyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(tertbutyldimethylsilyloxy)succinate
• Synonyms: (2S,3S)-1-(4-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutylamino)benzyl) 4-benzyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(tertbutyldimethylsilyloxy)succinate
• CAS NO: 1357485-73-4
• Molecular Weight: 887.158
• Mol File: 1357485-73-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3S)-1-(4-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutylamino)benzyl) 4-benzyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(tertbutyldimethylsilyloxy)succinate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S)-1-(4-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutylamino)benzyl) 4-benzyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(tertbutyldimethylsilyloxy)succinate(1357485-73-4)
• EPA Substance Registry System: (2S,3S)-1-(4-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutylamino)benzyl) 4-benzyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(tertbutyldimethylsilyloxy)succinate(1357485-73-4)

Safety Data

• Hazardous Substances Data: 1357485-73-4(Hazardous Substances Data)

Upstream product

• 19516-01-9 (2S,3S)-2-amino-4-(benzyloxy)-3-hydroxy-4-oxobutanoic acid 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 1357485-72-3 (2S,3S)-2-amino-4-(benzyloxy)-3-(tertbutyldimethylsilyloxy)-4-oxobutanoic acid 
• 172611-73-3 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl alcohol 
• 1357485-71-2 (2S,3S)-2-amino-4-(benzyloxy)-3-(tertbutyldimethylsilyloxy)-4-oxobutanoic acid 

Downstream Products

• 1357485-74-5 (2S,3S)-4-(4-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutylamino)benzyloxy)-3-(((9H-fluoren-9-yl)methoxy)carbonylamino)-2-(tert-butyldimethylsilyloxy)-4-oxobutanoic acid 

Relevant articles and documents

A practical synthesis of Nα-Fmoc protected L-threo-β-hydroxyaspartic acid derivatives for coupling via α- Or β-carboxylic group

A simple and practical general synthetic protocol towards orthogonally protected tHyAsp derivatives fully compatible with Fmoc solid-phase peptide synthetic methodology is reported. Our approach includes enantioresolution of commercially available D,L-tHyAsp racemic mixture by co-crystallization with L-Lys, followed by ion exchange chromatography yielding enantiomerically pure L-tHyAsp and D-tHyAsp, and their selective orthogonal protection. In this way Nα-Fmoc protected tHyAsp derivatives were prepared ready for couplings via either α- or β-carboxylic group onto the resins or the growing peptide chain. In addition, coupling of tHyAsp via β-carboxylic group onto amino resins allows preparation of peptides containing tHyAsn sequences, further increasing the synthetic utility of prepared tHyAsp derivatives. Springer-Verlag 2010.