135755-26-9

Upstream product

• 147030-72-6 benzo[1,3]dioxole-5-carboxylic acid methoxymethylamide 
• 25054-53-9 3,4-(methylenedioxy)benzoyl chloride 
• 861205-66-5 (Z)-1-benzo[1,3]dioxol-5-yl-3-tert-butoxypropenone 
• 135755-24-7 5-{(E)-3-[3-(3,4,5-Trimethoxy-phenyl)-prop-2-ynyloxy]-propenyl}-benzo[1,3]dioxole 
• 2675-79-8 1-bromo-3,4,5-trimethoxybenzene 

Relevant academic research and scientific papers

Radical-mediated synthesis of racemic deoxypodophyllotoxin and related lignans

An approach for the synthesis of lignans related to the podophyllotoxin family is reported. The key reaction is a highly diastereoselective iodoacetal cyclization under iodine atom transfer conditions followed by a hornolytic aromatic substitution. The second aromatic ring is introduced at a later stage via addition of aryllithium to an aryl ketone. A novel and very mild method for the deoxygenation of the intermediate tertiary benzylic alcohols is described. Georg Thieme Verlag Stuttgart.

SYNTHESIS OF DEHYDRODEOXYPODOPHYLLOTOXIN CYCLIC ETHER VIA ALLENE INTRAMOLECULAR CYCLOADDITION STRATEGY AND EVALUATION OF ITS CYTOTOXICITY

The new route to dehydrodeoxypodophyllotoxin cyclic ether (10) has been realized via allene intramolecular Diels-Alder reaction of the propargyl ether (8).