135758-77-9Relevant academic research and scientific papers
Application of the Ibuka-Yamamoto Reaction to a Problem in Stereochemical Communication: A Strategy for the Stereospecific Synthesis and Stabilization of the Triene Substructure of Rapamycin through Sulfone Substitution
Chen, Sui-Hui,Horvath, Raymond F.,Joglar, Jesus,Fisher, Matthew J.,Danishefsky, Samuel J.
, p. 5834 - 5845 (2007/10/02)
The aldehydes 49 and 55 corresponding to carbons 13-30 in a projected total synthesis of rapamycin have been synthesized.The LACDAC technology was used to elaborate dithiane enal 5.The aldehyde 4 was synthesized from D-(+)-glucose.A critical element of th
