1357586-70-9

Basic information

• Product Name: (3S,4S)-1-(tert-butoxycarbonyl)-3-(4-fluoro-2-methylphenyl)piperidine-4-carboxylic acid (S)-1-phenylethylamine complex
• Synonyms: (3S,4S)-1-(tert-butoxycarbonyl)-3-(4-fluoro-2-methylphenyl)piperidine-4-carboxylic acid (S)-1-phenylethylamine complex
• CAS NO: 1357586-70-9
• Molecular Weight: 458.573
• Mol File: 1357586-70-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3S,4S)-1-(tert-butoxycarbonyl)-3-(4-fluoro-2-methylphenyl)piperidine-4-carboxylic acid (S)-1-phenylethylamine complex(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,4S)-1-(tert-butoxycarbonyl)-3-(4-fluoro-2-methylphenyl)piperidine-4-carboxylic acid (S)-1-phenylethylamine complex(1357586-70-9)
• EPA Substance Registry System: (3S,4S)-1-(tert-butoxycarbonyl)-3-(4-fluoro-2-methylphenyl)piperidine-4-carboxylic acid (S)-1-phenylethylamine complex(1357586-70-9)

Safety Data

• Hazardous Substances Data: 1357586-70-9(Hazardous Substances Data)

Upstream product

• 30897-90-6 (2-methyl-4-fluorophenyl)magnesium bromide 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 40175-06-2 ethyl 1-methyl-1,2,5,6-tetrahydropyridine-4-carboxylate 

Downstream Products

• 1076229-22-5 (3S,4S)-1-[amino(oxo)acetyl]-N-[3,5-bis(trifluoromethyl)benzyl]-3-(4-fluoro-2-methylphenyl)-N-methylpiperidine-4-carboxamide 
• 1076230-21-1 (3S,4S)-N-[3,5-bis(trifluoromethyl)benzyl]-3-(4-fluoro-2-methylphenyl)-N-methylpiperidine-4-carboxamide monohydrochloride 
• 1076229-24-7 (3S,4S)-1-[amino(oxo)acetyl]-N-((1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl)-3-(4-fluoro-2-methylphenyl)-N-methylpiperidine-4-carboxamide 
• 1076230-18-6 (3S,4S)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-3-(4-fluoro-2-methylphenyl)-N-methylpiperidine-4-carboxamide monohydrochloride 
• 1076228-22-2 (3S,4S)-1-[amino(oxo)acetyl]-N-((1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl)-3-(4-fluoro-2-methylphenyl)-N-methylpiperidine-4-carboxamide 
• 873457-53-5 (3S,4S)-4-{N-1-(S)-(3,5-bistrifluoromethylphenyl)ethyl-N-methyl}aminocarbonyl-3-(4-fluoro-2-methylphenyl)piperidine 

Relevant articles and documents

Novel 3-phenylpiperidine-4-carboxamides as highly potent and orally long-acting neurokinin-1 receptor antagonists with reduced CYP3A induction

The synthesis and biological evaluation of a series of novel 3-phenylpiperidine-4-carboxamide derivatives are described. These compounds are generated by hybridization of the substructures from two types of tachykinin NK1 receptor antagonists.