(3S,4S)-1-(tert-butoxycarbonyl)-3-(4-fluoro-2-methylphenyl)piperidine-4-carboxylic acid (S)-1-phenylethylamine complex

Base Information

Chemical Name:(3S,4S)-1-(tert-butoxycarbonyl)-3-(4-fluoro-2-methylphenyl)piperidine-4-carboxylic acid (S)-1-phenylethylamine complex
CAS No.:1357586-70-9
Molecular Formula:C₈H₁₁N*C₁₈H₂₄FNO₄
Molecular Weight:458.573
Hs Code.:

Synonyms:(3S,4S)-1-(tert-butoxycarbonyl)-3-(4-fluoro-2-methylphenyl)piperidine-4-carboxylic acid (S)-1-phenylethylamine complex

Suppliers and Price of (3S,4S)-1-(tert-butoxycarbonyl)-3-(4-fluoro-2-methylphenyl)piperidine-4-carboxylic acid (S)-1-phenylethylamine complex

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S,4S)-1-(tert-butoxycarbonyl)-3-(4-fluoro-2-methylphenyl)piperidine-4-carboxylic acid (S)-1-phenylethylamine complex

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,4S)-1-(tert-butoxycarbonyl)-3-(4-fluoro-2-methylphenyl)piperidine-4-carboxylic acid (S)-1-phenylethylamine complex

There total 5 articles about (3S,4S)-1-(tert-butoxycarbonyl)-3-(4-fluoro-2-methylphenyl)piperidine-4-carboxylic acid (S)-1-phenylethylamine complex which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: (3RS,4RS)-1-(tert-butoxycarbonyl)-3-(4-fluoro-2-methylphenyl)piperidine-4-carboxylic acid

: 2627-86-3
(S)-1-phenyl-ethylamine

: 1357586-70-9
(3S,4S)-1-(tert-butoxycarbonyl)-3-(4-fluoro-2-methylphenyl)piperidine-4-carboxylic acid (S)-1-phenylethylamine complex

Guidance literature:: In acetone; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2011.11.048

Reference yield:

: 40175-06-2
ethyl 1-methyl-1,2,5,6-tetrahydropyridine-4-carboxylate

: 1357586-70-9
(3S,4S)-1-(tert-butoxycarbonyl)-3-(4-fluoro-2-methylphenyl)piperidine-4-carboxylic acid (S)-1-phenylethylamine complex

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide / diethyl ether / -10 - 0 °C

1.2: -50 - 10 °C

2.1: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 1 h / Reflux

2.2: 2 h / 80 °C

2.3: 14 h / 20 °C

3.1: sodium methylate / methanol / 3 h / Reflux

3.2: 3 h / 50 °C

4.1: acetone / 2 h / 20 °C

With copper(l) iodide; carbonochloridic acid 1-chloro-ethyl ester; sodium methylate; In methanol; diethyl ether; 1,2-dichloro-ethane; acetone;
DOI:10.1016/j.bmc.2011.11.048

Reference yield:

: C₁₆H₂₂FNO₂

: 1357586-70-9
(3S,4S)-1-(tert-butoxycarbonyl)-3-(4-fluoro-2-methylphenyl)piperidine-4-carboxylic acid (S)-1-phenylethylamine complex

Guidance literature:: Multi-step reaction with 3 steps

1.1: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 1 h / Reflux

1.2: 2 h / 80 °C

1.3: 14 h / 20 °C

2.1: sodium methylate / methanol / 3 h / Reflux

2.2: 3 h / 50 °C

3.1: acetone / 2 h / 20 °C

With carbonochloridic acid 1-chloro-ethyl ester; sodium methylate; In methanol; 1,2-dichloro-ethane; acetone;
DOI:10.1016/j.bmc.2011.11.048