13576-56-2Relevant academic research and scientific papers
Novel and efficient synthesis of 2-aminooxazoles from pyrimidin-2(1H)-one
Alifanov, Vadim L.,Babaev, Eugene V.
, p. 263 - 270 (2007/10/03)
Stepwise conversion of pyrimidin-2(1H)-one to 2-amino-5-aryloxazoles via oxazolo[3,2-a]pyrimidinium salts is reported. The sequence involves, (i) regioselective N-alkylation of pyrimidone by phenacyl bromides, (ii) cyclization of obtained 1-(2-aryl-2-oxoethyl)pyrimidin-2(1H)-ones into oxazolo[3,2-a] pyrimidinium salts under the action of fuming sulfuric (or triflic) acid, and (iii) reaction of the obtained salts with hydrazine leading to 2-amino-5-aryloxazoles. Georg Thieme Verlag Stuttgart.
Synthesis and reactions of N-o-anisylsulfonylmethyl- and N-o-sec-butoxysulfonylmethylcarbodiimides with aldehydes
Tandon, Vishnu K.,Singh, Kunwar A.,Rai, Sanjay,van Leusen, Albert M.
, p. 347 - 355 (2007/10/03)
N-o-Anisylsulfonylmethyl- and N-o-sec-butoxysulfonylmethyl-carbodiimides (2) and (3) have been synthesized from the corresponding sulfinic acids by Mannich reaction. 2 and 3 are useful synthons in two step synthesis of 2-amino-1,3-oxazoles(4).
FORMATION OF 2-ALKYLAMINOOXAZOLES BY THE Rh2(OAc)4-CATALYZED REACTION OF α-DIAZOCARBONYL COMPOUNDS IN THE PRESENCE OF CYANAMIDES
Fukushima, Kazuaki,Ibata, Toshikazu
, p. 149 - 154 (2007/10/02)
The Rh2(OAc)4-catalyzed reaction of α-diazoacetophenones with N,N-dialkylcyanamides gave the corresponding 2-(N,N-dialkylamino)-5-aryloxazoles in high yields.Although para-substituents of the diazoacetophenone and the N-alkyl groups of cyanamide did not a
Synthesis of N-(Tosylmethyl)carbodiimides and Their Application in the Synthesis of 2-Amino-1,3-oxazoles from Aldehydes
Leusen, Albert M. van,Jeuring, Hans J.,Wildeman, Jurjen,Nispen, Simon P. J. M. van
, p. 2069 - 2072 (2007/10/02)
A series of N-(tosylmethyl)carbodiimides (TosCH2N=C=NR1, 3) have been prepared from the corresponding thioureas.Carbodiimides 3 with R1 = triphenylmethyl or tert-butyl are useful synthons in a new one-step synthesis of 2-(alkylamino)-1,3-oxazoles 10 from aromatic aldehydes.Acid-induced removal of the triphenylmethyl group from 10 gives 2-amino-1,3-oxazoles (11).
