933053-13-5

Basic information

• Product Name: 1-[2-(4-nitrophenyl)-2-oxoethyl]pyrimidin-2(1H)-one
• Synonyms: 1-[2-(4-nitrophenyl)-2-oxoethyl]pyrimidin-2(1H)-one
• CAS NO: 933053-13-5
• Molecular Weight: 259.221
• Mol File: 933053-13-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-[2-(4-nitrophenyl)-2-oxoethyl]pyrimidin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(4-nitrophenyl)-2-oxoethyl]pyrimidin-2(1H)-one(933053-13-5)
• EPA Substance Registry System: 1-[2-(4-nitrophenyl)-2-oxoethyl]pyrimidin-2(1H)-one(933053-13-5)

Safety Data

• Hazardous Substances Data: 933053-13-5(Hazardous Substances Data)

Upstream product

• 38353-09-2 2-pyrimidinone hydrochloride 
• 99-81-0 4-Nitrophenacyl bromide 

Downstream Products

• 13576-56-2 5-(4-nitrophenyl)-1,3-oxazol-2-amine 

Relevant articles and documents

Novel and efficient synthesis of 2-aminooxazoles from pyrimidin-2(1H)-one

Stepwise conversion of pyrimidin-2(1H)-one to 2-amino-5-aryloxazoles via oxazolo[3,2-a]pyrimidinium salts is reported. The sequence involves, (i) regioselective N-alkylation of pyrimidone by phenacyl bromides, (ii) cyclization of obtained 1-(2-aryl-2-oxoethyl)pyrimidin-2(1H)-ones into oxazolo[3,2-a] pyrimidinium salts under the action of fuming sulfuric (or triflic) acid, and (iii) reaction of the obtained salts with hydrazine leading to 2-amino-5-aryloxazoles. Georg Thieme Verlag Stuttgart.