135782-16-0

Basic information

• Product Name: (S)-1-Phenyl-N-((trimethylsilyl)methyl)ethanamine
• Synonyms: (S)-1-Phenyl-N-((trimethylsilyl)methyl)ethanamine;(S)-(1-Phenyl-ethyl)-trimethylsilanylmethyl-amine
• CAS NO: 135782-16-0
• Molecular Formula: C₁₂H₂₁NSi
• Molecular Weight: 207.38734
• Mol File: 135782-16-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-1-Phenyl-N-((trimethylsilyl)methyl)ethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-Phenyl-N-((trimethylsilyl)methyl)ethanamine(135782-16-0)
• EPA Substance Registry System: (S)-1-Phenyl-N-((trimethylsilyl)methyl)ethanamine(135782-16-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 135782-16-0(Hazardous Substances Data)

Usage

General Description

(S)-1-Phenyl-N-((trimethylsilyl)methyl)ethanamine is a chemical compound with a molecular formula of C12H19NSi. It is a chiral amine with a phenyl group and a trimethylsilylmethyl group attached to the nitrogen atom. (S)-1-Phenyl-N-((trimethylsilyl)methyl)ethanamine is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. The trimethylsilyl group provides stability and protection to the amine, making it easier to handle and manipulate in chemical reactions. It is also used as a reagent in the preparation of chiral amine derivatives. (S)-1-Phenyl-N-((trimethylsilyl)methyl)ethanamine has applications in various fields of organic chemistry, making it a valuable building block for the synthesis of complex molecules.

Upstream product

• 2627-86-3 (S)-1-phenyl-ethylamine 
• 2344-80-1 Chloromethyltrimethylsilane 

Downstream Products

• 143140-08-3 N-(S)-α-methylbenzyl-N-(methoxymethyl)-N-((trimethylsilyl)methyl)amine 
• 134139-08-5 (S)-(-)-N-1-Phenylethyl-N-(octyloxymethyl)trimethylsilyl methylamine 
• 134139-06-3 (S)-(-)-N-1-phenylethyl-N-(butoxymethyl)trimethylsilylmethylamine 
• 134234-15-4 (3R,4S)-3-ethoxycarbonyl-1-<(S)-1-phenylethyl>-1-azoniabicyclo<2.2.1>heptane bromide 
• 134234-26-7 (3aS,7aR)-2-<(S)-1-phenylethyl>-perhydropyrano<3,4-c>pyrrol-4-one 
• 134234-25-6 (3aR,7aS)-2-<(S)-1-phenylethyl>-perhydropyrano<3,4-c>pyrrol-4-one 
• 104942-75-8 (3R,4S)-3-Benzo[1,3]dioxol-5-yl-4-nitro-1-((S)-1-phenyl-ethyl)-pyrrolidine 
• 104942-76-9 5-Phenyl-3-((S)-1-phenyl-ethyl)-oxazolidine 
• 177696-20-7 (3S,5aS,8aR,8bR)-3-Phenyl-7-((S)-1-phenyl-ethyl)-octahydro-pyrrolo[3',4':3,4]pyrrolo[2,1-b]oxazol-5-one 
• 177696-32-1 (3S,5aR,8aR,8bR)-5a-Bromo-3-phenyl-7-((S)-1-phenyl-ethyl)-octahydro-pyrrolo[3',4':3,4]pyrrolo[2,1-b]oxazol-5-one 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS FOR MEDIATING TYROSINE KINASE 2 ACTIVITY

Heterocyclic compounds shown in Formula (I) suitable for inhibiting or regulating the activity of Janus kinase (JAK), particularly tyrosine kinase 2 (TYK2). The compounds are useful for preventing and/or treating relevant JAK-mediated diseases, such as autoimmune diseases, inflammatory diseases, and cancers.

QUINOLONE ANTIBACTERIAL AGENTS

Compounds of formula (I) wherein A is formula (II), formula (III) or formula (IV), and B is formula (V), formula (VI), or formula (VII), can be used in a variety of applications including use as antibacterial agents.

Non-stabilized azomethine ylides in [3 + 2] cycloadditions. Pyrrolidinylfuranones from (5S)-5-menthyloxy-4-vinylfuran-2(5H)-one

Upon sonication with lithium fluoride in acetonitrile N-benzyl-N-methoxymethyl(trimethylsilylmethyl)amines 9a-c undergo chemoselective 1,3-dipolar cycloaddition with 4-vinylfuranones 2 and 6 to afford pyrrolidinylfuranones 10, 11a-c and 12a-c. The stereochemistry is assigned by X-ray analyses and proton NMR data comparison of related oxiranylfuranone 13.