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Usage

Uses

Used in Pharmaceutical Synthesis:
(S)-1-Phenyl-N-((trimethylsilyl)methyl)ethanamine is used as an intermediate in the synthesis of pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique structure and properties make it a valuable component in the creation of complex molecular structures.
Used in Agrochemical Production:
In the agrochemical industry, (S)-1-Phenyl-N-((trimethylsilyl)methyl)ethanamine serves as an intermediate for the synthesis of various agrochemicals, including pesticides and other compounds that aid in crop protection and enhancement.
Used in Organic Chemistry:
(S)-1-Phenyl-N-((trimethylsilyl)methyl)ethanamine is also utilized as a reagent in the preparation of chiral amine derivatives, which are essential in organic chemistry for the synthesis of a wide range of compounds with specific stereochemistry.
Used in Chemical Research:
(S)-1-Phenyl-N-((trimethylsilyl)methyl)ethanamine is a valuable building block for researchers in the field of organic chemistry, as it allows for the exploration of new synthetic pathways and the development of novel chemical methodologies.

Upstream product

• 2627-86-3 (S)-1-phenyl-ethylamine 
• 2344-80-1 Chloromethyltrimethylsilane 

Downstream Products

• 104942-84-9 R(+)-N-(1-phenylethyl)-N-cyanomethyl-N-trimethylsilylmethylamine 
• 134139-06-3 (S)-(-)-N-1-phenylethyl-N-(butoxymethyl)trimethylsilylmethylamine 
• 143140-08-3 N-(S)-α-methylbenzyl-N-(methoxymethyl)-N-((trimethylsilyl)methyl)amine 
• 177696-32-1 (3S,5aR,8aR,8bR)-5a-Bromo-3-phenyl-7-((S)-1-phenyl-ethyl)-octahydro-pyrrolo[3',4':3,4]pyrrolo[2,1-b]oxazol-5-one 
• 177696-20-7 (3S,5aS,8aR,8bR)-3-Phenyl-7-((S)-1-phenyl-ethyl)-octahydro-pyrrolo[3',4':3,4]pyrrolo[2,1-b]oxazol-5-one 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS FOR MEDIATING TYROSINE KINASE 2 ACTIVITY

Heterocyclic compounds shown in Formula (I) suitable for inhibiting or regulating the activity of Janus kinase (JAK), particularly tyrosine kinase 2 (TYK2). The compounds are useful for preventing and/or treating relevant JAK-mediated diseases, such as autoimmune diseases, inflammatory diseases, and cancers.

Saturated abnormal NHC-gold(I) complexes: Synthesis and catalytic activity

New saturated abnormal N-heterocyclic carbene complexes of gold(I) have been prepared by a 1,3-dipolar cycloaddition of an in situ generated azomethine ylide with an isocyanogold(I) choride. A series of different substituents on the nitrogen atom of the 1

QUINOLONE ANTIBACTERIAL AGENTS

Compounds of formula (I) wherein A is formula (II), formula (III) or formula (IV), and B is formula (V), formula (VI), or formula (VII), can be used in a variety of applications including use as antibacterial agents.

ANTIBACTERIAL AMINOQUINAZOLIDINEDIONE DERIVATIVES

Compounds of formula (I) wherein: A is Formula (II), Formula (III), or Formula (IV) and B is Formula (V), Formula (VI), or Formula (VII), can be used in a variety of applications including use as antibacterial agents.

Non-stabilized azomethine ylides in [3 + 2] cycloadditions. Pyrrolidinylfuranones from (5S)-5-menthyloxy-4-vinylfuran-2(5H)-one

Upon sonication with lithium fluoride in acetonitrile N-benzyl-N-methoxymethyl(trimethylsilylmethyl)amines 9a-c undergo chemoselective 1,3-dipolar cycloaddition with 4-vinylfuranones 2 and 6 to afford pyrrolidinylfuranones 10, 11a-c and 12a-c. The stereochemistry is assigned by X-ray analyses and proton NMR data comparison of related oxiranylfuranone 13.

Single and double diastereoselection in azomethine ylide cycloaddition reactions with unsaturated chiral bicyclic lactams

Double diastereoselectivity data were analyzed to provide insight into the structural features that influence π-facial selectivity in 1,3-dipolar cycloadditions of chiral and achiral azomethine ylides to chiral, unsaturated bicyclic lactams. Three major steric contributions to the differences in stability (ΔΔG(≠)) between competing cycloaddition transition states were identified. The first major set of steric interactions involve that between the dipoles and the substituents on the left hemisphere (R2) and concave faces of the bicyclic lactams. This effectively hindered both α- and β-approaches in the nonextended transition states. The second major steric interaction was provided by the nonbonded interactions (i) between the R1 angular substituent on the bicyclic lactam and the π-system of the dipole. This interaction was shown to be very significant, causing reversal in π-facial attack of chiral and achiral dipoles when the angular substituent is changed from phenyl or methyl to hydrogen. The high diastereoselectivity observed now opens a route to highly substituted chiral, nonracemic pyrrolidines.

Diastereofacial selectivity in azomethine ylide cycloaddition reactions derived from chiral α-cyanoaminosilanes

A series of α-cyanoaminosilanes has been found to act as azomethine ylide equivalents. Treatment of these compounds with silver fluoride in the presence of electron deficient olefins gives substituted pyrrolidines in high yield. The extent ofdiastereoselectivity associated with the 1,3-dipolar cycloaddition of chiral azomethine ylides with several dipolarophiles has been studied. Reasonable levels of such diastereoselectivity have been found when optically active α-cyanoaminosilanes are employed as azomethine ylide equivalents. These compounds can be prepared in multigram quantities by treating the appropriate chiral amine with chlorotrimethylsilane followed by reaction of the resulting secondary amine with formaldehyde in the presence of potassium cyanide. It was found that N-benzyl-N-cyanomethyl-N-trimethylsilylmethylamine undergoes stereospecific cycloaddition with dimethyl fumarate and maleate. The stereospecificity of the reaction is consistent with a concerted cycloaddition reaction.