135782-19-3

Usage

Uses

Used in Pharmaceutical Industry:
2-Morpholinecarboxylic acid, methyl ester (9CI) is used as a chemical intermediate for the synthesis of various pharmaceuticals. It plays a crucial role in the development of new drugs and the improvement of existing ones, contributing to advancements in healthcare and medicine.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Morpholinecarboxylic acid, methyl ester (9CI) serves as an intermediate in the production of agrochemicals, such as pesticides and herbicides. Its use in this sector helps to develop more effective and safer products for agricultural applications, ensuring better crop protection and increased yields.
Used as a Solvent:
2-Morpholinecarboxylic acid, methyl ester (9CI) is utilized as a solvent in various chemical processes. Its properties make it suitable for dissolving and mixing with other substances, facilitating reactions and improving the efficiency of chemical synthesis.
Used as an Intermediate in Chemical Production:
2-Morpholinecarboxylic acid, methyl ester (9CI) is also used as an intermediate in the production of other chemical substances. Its versatility in chemical reactions allows it to be a valuable component in the synthesis of a wide range of compounds, contributing to the diversity of chemical products available in the market.

InChI:InChI=1/C6H11NO3/c1-9-6(8)5-4-7-2-3-10-5/h5,7H,2-4H2,1H3

Upstream product

• 135782-22-8 Morpholine-2,4-dicarboxylic acid 4-benzyl ester 2-methyl ester 
• 500789-41-3 4-(t-butyloxycarbonyl)morpholine-2-carboxylic acid methyl ester 
• 189321-66-2 4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid 
• 135782-20-6 2-Hydroxymethyl-4-benzyloxycarbonyl-morpholine 
• 40987-24-4 R,S-2-hydroxymethyl-4-benzylmorpholine 

Downstream Products

• 31633-70-2 methyl 3-carbomethoxy-4-oxo-1-piperidinecarboxylate 
• 135782-25-1 2-morpholinecarboxylic acid ethyl ester 

Relevant academic research and scientific papers

JAK INHIBITOR

The present invention discloses a series of JAK inhibitors, and particularly discloses a compound of formula (I) or a pharmaceutically acceptable salt thereof and the use thereof in preparation of drugs for treating diseases related to JAK.

PYRIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS

There are provided according to the invention novel compounds of formula (I) or a pharmaceutically acceptable salt thereof: (I) wherein: X represents a nitrogen atom; Y represents -C(H2)-, (-C(H2)-)2, -S(O2)- or -C(=O)-; Z represents -C(H2)-, -S(O2)-, -N(Rz)-, or an oxygen or sulphur atom; A represents hydrogen or -CH2OH; Rz represents hydrogen, C1-6 alkyl, C1-6 alkoxy, -COR7 or -SO2R7; R1 represents halogen, C1-6 alkyl, C1-6 alkoxy, =O, haloC1-6 alkyl, haloC1-6 alkoxy, hydroxyl or -CH2OH; m represents an integer from 0 to 3; R2 represents halogen, =O, C1-6alkyl (optionally substituted by one or more hydroxyl groups), -COOR7, -CONR7R8, C1-6 alkoxy, haloC1-6 alkyl, haloC1-6alkoxy or C1-6 alkyloC1-6 alkyl; n represents an integer from 0 to 3; p and q independently represent an integer from 0 to 2; R3 represents an -aryl, -heteroaryl, -heterocyclyl, -aryl-aryl, -aryl-heteroaryl, -aryl-heterocyclyl, -heteroaryl-aryl, -heteroaryl-heteroaryl, -heteroaryl-heterocyclyl, -heterocyclyl-aryl, -heterocyclyl-heteroaryl or -heterocyclyl-heterocyclyl group, all of which may be optionally substituted by one or more (e.g. 1, 2 or 3) halogen, C1-6 alkyl (optionally substituted by one or more hydroxyl groups), C3-8cycloalkyl, C1-6 alkoxy, hydroxyl, haloC1-6alkyl, haloC1-6 alkoxy, cyano, -S-C1-6 alkyl, -SO-C1-6 alkyl, -SO2-C1-6 alkyl, -COR7, -CONR7R8, -NR7R8, -NR7COC1-6 alkyl, -NR7SO2-C1-6alkyl, C1-6 alkyl-NR7R8, -OCONR7R8 , -NR7CO2R8 or -SO2NR7R8 groups; R4 and R5 independently represent C1-6 alkyl, or R4 and R5 together with the carbon atom to which they are attached may together form a C3-8cycloalkyl group; R6 represents halogen, C1-6 alkyl, C3-8cycloalkyl, C1-6 alkoxy, haloC1-6 alkyl or haloC1-6 alkoxy; s represents an integer from 0 to 4; R7 and R8 independently represent hydrogen, C1-6 alkyl or C3-8cycloalkyl; or solvates thereof.

The synthesis of 2-morpholine carboxylic acid derivatives and their elaboration to 1-aza-4-oxabicyclo[3.3.1]nonan-6-one

Two syntheses of novel 2-morpholine carboxylic acid derivatives are described. The esters were converted into 1-aza-4-oxabicyclo[3.3.1]nonan-6-one, the first example of this ring system, which was further elaborated to the ortho-methoxy benzamide derivative (2).