40987-24-4

Basic information

• Product Name: (4-BENZYL-1,4-OXAZINAN-2-YL)METHANOL
• Synonyms: 2-HYDROXYMETHYL-4-BENZYLMORPHOLINE;(4-BENZYL-1,4-OXAZINAN-2-YL)METHANOL;4-BENZYL-2-(HYDROXYMETHYL)MORPHOLINE;(4-BENZYLMORPHOLIN-2-YL)METHANOL;BUTTPARK 98\04-20;2-Morpholinemethanol, 4-(phenylmethyl)-;4-(PhenylMethyl)-2-MorpholineMethanol;4-Benzyl-2-MorpholineMethanol
• CAS NO: 40987-24-4
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.27
• Product Categories: pharmacetical;Heterocycles;Intermediates
• Mol File: 40987-24-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 114°C 0,05mm
• Flash Point: 137.2 °C
• Appearance: Green oil
• Density: 1.118 g/cm³
• Vapor Pressure: 0.000415mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 14.36±0.10(Predicted)
• CAS DataBase Reference: (4-BENZYL-1,4-OXAZINAN-2-YL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (4-BENZYL-1,4-OXAZINAN-2-YL)METHANOL(40987-24-4)
• EPA Substance Registry System: (4-BENZYL-1,4-OXAZINAN-2-YL)METHANOL(40987-24-4)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 24/25-39-26
• Hazardous Substances Data: 40987-24-4(Hazardous Substances Data)

Usage

Chemical Properties

Green Oil

Uses

Intermediate in the preparation of various antidepressants and protein kinase inhibitors.

InChI:InChI=1/C12H17NO2/c14-10-12-9-13(6-7-15-12)8-11-4-2-1-3-5-11/h1-5,12,14H,6-10H2/p+1/t12-/m0/s1

Upstream product

• 40987-25-5 N-benzyl-2-chloromethylmorpholine 
• 174560-84-0 1-chloro-3-[(2-hydroxyethyl)(phenylmethyl)amino]-2-propanol 
• 769087-80-1 4-benzylmorpholine-2-carboxylic acid 
• 104-63-2 N-Benzylethanolamine 
• 61636-32-6 5S-N-Benzylmorpholin-3-one 

Downstream Products

• 103003-01-6 morpholin-2-ylmethanol 
• 1215229-28-9 2-[(4-benzylmorpholin-2-yl)methoxy]-N-[(2Z)-5-tert-butyl-3-[(2S)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-(trifluoromethyl)benzamide 
• 130546-33-7 4-t-butoxycarbonyl-2-[(4-methylphenylsulphonyloxy)methyl]morpholine 

Relevant articles and documents

Synthesis and Initial Characterization of a Selective, Pseudo-irreversible Inhibitor of Human Butyrylcholinesterase as PET Tracer

The enzyme butyrylcholinesterase (BChE) represents a promising target for imaging probes to potentially enable early diagnosis of neurodegenerative diseases like Alzheimer's disease (AD) and to monitor disease progression in some forms of cancer. In this study, we present the design, facile synthesis, in vitro and preliminary ex vivo and in vivo evaluation of a morpholine-based, selective inhibitor of human BChE as a positron emission tomography (PET) tracer with a pseudo-irreversible binding mode. We demonstrate a novel protecting group strategy for 18F radiolabeling of carbamate precursors and show that the inhibitory potency as well as kinetic properties of our unlabeled reference compound were retained in comparison to the parent compound. In particular, the prolonged duration of enzyme inhibition of such a morpholinocarbamate motivated us to design a PET tracer, possibly enabling a precise mapping of BChE distribution.

NOVEL PYRIMIDINE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL USE THEREOF AS AKT(PKB) PHOSPHORYLATION INHIBITORS

The present invention relates to novel chemical compounds derived from pyrimidines, to the method for preparing same, to the novel intermediates obtained, to the use thereof as drugs, to the pharmaceutical compositions containing same, and to the therapeutic use thereof as AKT inhibitors.

Concise synthesis of (S)-N-BOC-2-hydroxymethylmorpholine and (S)-N-BOC-morpholine-2-carboxylic acid

(Chemical Equation Presented) An operationally simple synthesis of N-BOC-2-hydroxymethylmorpholine (1) and N-BOC-morpholine-2-carboxylic acid (2) from epichlorohydrin has been developed. No chromatography is required in the processing, which allows high p