13580-86-4

Usage

Uses

Used in Pharmaceutical Industry:
4-Chlorophthalazin-1-ylamine is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its ability to form derivatives with potential biological activities makes it a valuable building block in the development of new drugs.
Used in Anthelmintic Applications:
In the veterinary pharmaceutical industry, 4-chlorophthalazin-1-ylamine is used as a starting material to prepare 2-phenylimidazo[1,2-b]pyridazine derivatives. These derivatives exhibit anthelminthic properties, making them effective against parasitic worms, particularly Haemonchus contortus, a common gastrointestinal parasite in sheep and goats.
Used in Inhibitor Development:
4-Chlorophthalazin-1-ylamine is also utilized in the synthesis of imidazo[2,1-a]phthalazines, which are potential inhibitors of p38 MAP kinase. This enzyme plays a crucial role in various cellular processes, including inflammation, immune responses, and cell growth. Inhibiting p38 MAP kinase activity can be beneficial in the treatment of various diseases, such as autoimmune disorders and cancer.
Used in Computational Biology:
The compound is employed in the prediction of binding affinities of protein ligands, which is an essential aspect of drug design and development. By understanding how 4-chlorophthalazin-1-ylamine interacts with target proteins, researchers can gain insights into its potential applications and optimize its properties for specific therapeutic purposes.

InChI:InChI=1/C8H6ClN3/c9-7-5-3-1-2-4-6(5)8(10)12-11-7/h1-4H,(H2,10,12)

Upstream product

• 4752-10-7 1,4-dichlorophthalazine 
• 1445-69-8 2,3-dihydrophthalazine-1,4-dione 

Downstream Products

• 449187-70-6 6-chloro-2-phenyl-imidazo[2,1-a]phthalazine 
• 19064-69-8 phthalazin-1-ylamine 
• 1428340-19-5 C₂₄H₁₈ClN₃O₂ 
• 1428340-20-8 C₁₆H₁₂ClN₃O 
• 40227-66-5 4-benzoylamino-2H-phthalazin-1-one 
• 108784-46-9 6-chloro-3-methoxy-2-phenylimidazo<2,1-a>phthalazine 
• 449187-73-9 6-chloro-2-(4-fluoro-phenyl)-3-iodo-imidazo[2,1-a]phthalazine 
• 449187-72-8 6-chloro-3-iodo-2-phenyl-imidazo[2,1-a]phthalazine 
• 449187-71-7 6-chloro-2-(4-fluoro-phenyl)-imidazo[2,1-a]phthalazine 

Relevant academic research and scientific papers

PHTHALAZINE DERIVATIVES

Compounds of the formula (I), in which R1, X and n have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous syst

Design, synthesis, and molecular modelling of pyridazinone and phthalazinone derivatives as protein kinases inhibitors

The design and synthesis of pyridazinone and phthalazinone derivatives are described. Newly synthesized compounds were tested on a panel of four kinases in order to evaluate their activity and potential selectivity. In addition, the promising compounds were tested on four cancer cell lines to examine cytotoxic effects. The compounds inhibited DYRK1A and GSK3 with different activity. SAR analysis and docking calculations were carried out to aid in the interpretation of the results. Taken together, our findings suggest that pyridazinone and phthalazinone scaffolds are interesting starting points for design of potent GSK3 and DYRK1A inhibitors.

TRIAZOLO-PYRIDAZINE COMPOUNDS AND DERIVATIVES THEREOF USEFUL IN THE TREATMENT OF NEUROPATHIC PAIN

The present invention is directed to a method of use of triazolo-pyridazine compounds in the treatment of neuropathic pain. The present invention is also directed to the use of triazolo-pyridazine compounds in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, bipolar disorders, and panic, as well as in the treatment of pain, Parkinson’s disease, cognitive dysfunction, epilepsy, circadian rhythm and sleep disorders - such as shift-work induced sleep disorder and jet-lag, drug addiction, drug abuse, drug withdrawal and other diseases. The present invention is also directed to novel triazolo-pyridazine compounds that selectively bind to α2δ-1 subunit of Ca channels.

SPECTRA AND STRUCTURE OF 1-AMINOPHTHALAZINES

On the basis of UV and PMR spectroscopic data with the aid of the method of experimental structures and the method of dipole moments it was concluded that the products of the reaction of 1,4-dichlorophthalazine with ammonia, methylamine, and aniline in so