135829-05-9

Upstream product

• 210364-11-7 2,3-Dihydro-indole-1,2-dicarboxylic acid 1-benzyl ester 2-ethyl ester 
• 3770-50-1 2-carbethoxyindole 
• 79-37-8 oxalyl dichloride 
• 135829-04-8 benzyl 2-(Hydroxymethyl)-1-indolinecarboxylate 
• 497-19-8 sodium carbonate 
• 135829-03-7 methyl (+/-)-1-benzyloxycarbonyl-indoline-2-carboxylate 
• 16851-56-2 indolin-2-yl carboxylic acid 
• 501-53-1 benzyl chloroformate 

Relevant academic research and scientific papers

Aldolase-catalyzed synthesis of conformationally constrained iminocyclitols: Preparation of polyhydroxylated benzopyrrolizidines and cyclohexapyrrolizidines

A straightforward chemo-enzymatic synthesis of new polyhydroxylated benzopyrrolizidines and cyclohexapyrrolizidines is developed. The two-step strategy consists of l-fuculose-1-phosphate aldolase variant F131A-catalyzed aldol addition of dihydroxyacetone phosphate to rac-N-benzyloxycarbonylindoline- 2-carbaldehyde as well as (2S*,3aS*,7aS*)- and (2S*,3aR*,7aR*)-N-benzyloxycarbonyloctahydroindole-2- carbaldehydes and a subsequent one-step catalytic deprotection-reductive amination.

Synthesis and antibacterial activity of [6,5,5] and [6,6,5] tricyclic fused oxazolidinones

A series of conformationally restricted, [6,5,5] and [6,6,5] tricyclic fused oxazolidinones were synthesized and tested for antibacterial activity. Several compounds in the trans-[6,5,5] series demonstrated potent in vitro and in vivo activity. This work provides valuable information regarding the preferred conformational orientation of the oxazolidinones at the binding site.

Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents

The present invention involves tricyclic-fused 6-member ring oxazolidinones STR1 and tricyclic-fused 5-member ring oxazolidinones STR2 which are useful as antibacterial agents.