135865-60-0

Basic information

• Product Name: 1-(10,10-dioxidophenoxathiin-1-yl)ethane-1,2-diol
• Synonyms: 1,2-ethanediol, 1-(10,10-dioxido-1-phenoxathiinyl)-
• CAS NO: 135865-60-0
• Molecular Formula: C₁₄H₁₂O₅S
• Molecular Weight: 292.3071
• Mol File: 135865-60-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 572.6°C at 760 mmHg
• Flash Point: 300.1°C
• Density: 1.52g/cm³
• Vapor Pressure: 5.94E-14mmHg at 25°C
• Refractive Index: 1.675
• CAS DataBase Reference: 1-(10,10-dioxidophenoxathiin-1-yl)ethane-1,2-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(10,10-dioxidophenoxathiin-1-yl)ethane-1,2-diol(135865-60-0)
• EPA Substance Registry System: 1-(10,10-dioxidophenoxathiin-1-yl)ethane-1,2-diol(135865-60-0)

Safety Data

• Hazardous Substances Data: 135865-60-0(Hazardous Substances Data)

Upstream product

• 135865-59-7 1-(1-Hydroxyethyl)-phenoxathiin-10,10-dioxide 
• 950-47-0 phenoxathiin S,S-dioxide 
• 135865-62-2 1-vinylphenoxathiin 10,10-dioxide 

Relevant articles and documents

Selective inhibitors of monoamine oxidase (MAO). 5.1,2 1-Substituted phenoxathiin inhibitors containing no nitrogen that inhibit MAO a by binding it to a hydrophobic site

It is believed that a monoamine oxidase (MAO) inhibitor specific for MAO A, which is reversibly bound to this enzyme and displaceable by tyramine, will be an antidepressant which will not cause a rise in blood pressure when tyramine-containing foods are ingested. Some linear tricyclic compounds with a larger and a smaller group forming the central ring and with a lipophilic group ortho to the larger group (here mostly the SO2 function of phenoxathiin 10,10-dioxide) are reported to have the sought properties. Potency appears to require short length and relatively small cross section for the substituent. The 1-ethyl (13), 1-vinyl (22), 1-trifluoromethyl (27), and 1-iodo (76) phenoxathiin dioxides had the best profiles. Structure- activity relationships, syntheses, and a possible rationale for the selectivity of these compounds and related tricyclics are given. Compound 13 was selected for further development. A summary of pharmacological data for 13 is given.